Fabrication of a three-dimensional nanostructured biomaterial for tissue engineering of bone

E. Garreta; D. Gasset; C. Semino; S. Borrós

doi:10.1016/j.bioeng.2006.05.017

Fabrication of a three-dimensional nanostructured biomaterial for tissue engineering of bone

E. Garreta
, D. Gasset
, C. Semino
, S. Borrós^*

^*Autor corresponent d’aquest treball

Producció científica: Article en revista indexada › Article › Avaluat per experts

41 Cites (Scopus)

Resum

A plasma process for the surface modification of HA powders has been developed. Acrylic acid and acrylic acid/octadiene plasma deposited films onto HA particles have demonstrated to interact with SBF allowing the calcium dissolution-precipitation mechanism. Therefore, a nanostructured composite between HA and a self-assembling peptide scaffold (RAD16-I) has been developed. The differentiation of mESC in this scaffold has been studied, in order to test the osteogenic capacity of the new composite material. We have observed that the mESC can be iduced to produce Ca salts (mineralization) in a 3D-microenvironment and moreover, this activity can be enhanced by the presence of HA particules into the nanofiber scaffold.

Idioma original	Anglès
Pàgines (de-a)	75-80
Nombre de pàgines	6
Revista	Biomolecular Engineering
Volum	24
Número	1 SPEC. ISS.
DOIs	https://doi.org/10.1016/j.bioeng.2006.05.017
Estat de la publicació	Publicada - de febr. 2007
Esdeveniment	Symposium on Nano-Structured and Intelligent Bioactive Materials held at the EMRS 2005 Spring Meeting - Strasbourg, France Durada: 29 de maig 2005 → 2 de juny 2005

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@article{4b822d521d4b40c5bbdbd41591ababab,

title = "Fabrication of a three-dimensional nanostructured biomaterial for tissue engineering of bone",

abstract = "A plasma process for the surface modification of HA powders has been developed. Acrylic acid and acrylic acid/octadiene plasma deposited films onto HA particles have demonstrated to interact with SBF allowing the calcium dissolution-precipitation mechanism. Therefore, a nanostructured composite between HA and a self-assembling peptide scaffold (RAD16-I) has been developed. The differentiation of mESC in this scaffold has been studied, in order to test the osteogenic capacity of the new composite material. We have observed that the mESC can be iduced to produce Ca salts (mineralization) in a 3D-microenvironment and moreover, this activity can be enhanced by the presence of HA particules into the nanofiber scaffold.",

keywords = "Bone tissue engineering, Cartilage, Hydroxyapatite, Nanostructured composite",

author = "E. Garreta and D. Gasset and C. Semino and S. Borr{\'o}s",

note = "Funding Information: We are grateful to Alan Grodzinsky for facilitating the performance of this work at the Center for Biomedical Engineering. E.G. was supported by a fellowship from the Institut Quim{\'i}c de Sarri{\`a} (IQS).; Symposium on Nano-Structured and Intelligent Bioactive Materials held at the EMRS 2005 Spring Meeting ; Conference date: 29-05-2005 Through 02-06-2005",

year = "2007",

month = feb,

doi = "10.1016/j.bioeng.2006.05.017",

language = "English",

volume = "24",

pages = "75--80",

journal = "Biomolecular Engineering",

issn = "1389-0344",

publisher = "Elsevier B.V.",

number = "1 SPEC. ISS.",

}

TY - JOUR

T1 - Fabrication of a three-dimensional nanostructured biomaterial for tissue engineering of bone

AU - Garreta, E.

AU - Gasset, D.

AU - Semino, C.

AU - Borrós, S.

N1 - Funding Information: We are grateful to Alan Grodzinsky for facilitating the performance of this work at the Center for Biomedical Engineering. E.G. was supported by a fellowship from the Institut Quimíc de Sarrià (IQS).

PY - 2007/2

Y1 - 2007/2

N2 - A plasma process for the surface modification of HA powders has been developed. Acrylic acid and acrylic acid/octadiene plasma deposited films onto HA particles have demonstrated to interact with SBF allowing the calcium dissolution-precipitation mechanism. Therefore, a nanostructured composite between HA and a self-assembling peptide scaffold (RAD16-I) has been developed. The differentiation of mESC in this scaffold has been studied, in order to test the osteogenic capacity of the new composite material. We have observed that the mESC can be iduced to produce Ca salts (mineralization) in a 3D-microenvironment and moreover, this activity can be enhanced by the presence of HA particules into the nanofiber scaffold.

AB - A plasma process for the surface modification of HA powders has been developed. Acrylic acid and acrylic acid/octadiene plasma deposited films onto HA particles have demonstrated to interact with SBF allowing the calcium dissolution-precipitation mechanism. Therefore, a nanostructured composite between HA and a self-assembling peptide scaffold (RAD16-I) has been developed. The differentiation of mESC in this scaffold has been studied, in order to test the osteogenic capacity of the new composite material. We have observed that the mESC can be iduced to produce Ca salts (mineralization) in a 3D-microenvironment and moreover, this activity can be enhanced by the presence of HA particules into the nanofiber scaffold.

KW - Bone tissue engineering

KW - Cartilage

KW - Hydroxyapatite

KW - Nanostructured composite

UR - https://www.scopus.com/pages/publications/33846874385

UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=pure_univeritat_ramon_llull&SrcAuth=WosAPI&KeyUT=WOS:000245004900012&DestLinkType=FullRecord&DestApp=WOS_CPL

U2 - 10.1016/j.bioeng.2006.05.017

DO - 10.1016/j.bioeng.2006.05.017

M3 - Article

C2 - 16846750

AN - SCOPUS:33846874385

SN - 1389-0344

VL - 24

SP - 75

EP - 80

JO - Biomolecular Engineering

JF - Biomolecular Engineering

IS - 1 SPEC. ISS.

T2 - Symposium on Nano-Structured and Intelligent Bioactive Materials held at the EMRS 2005 Spring Meeting

Y2 - 29 May 2005 through 2 June 2005

ER -

Fabrication of a three-dimensional nanostructured biomaterial for tissue engineering of bone

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