TY - JOUR
T1 - Fabrication of a three-dimensional nanostructured biomaterial for tissue engineering of bone
AU - Garreta, E.
AU - Gasset, D.
AU - Semino, C.
AU - Borrós, S.
N1 - Funding Information:
We are grateful to Alan Grodzinsky for facilitating the performance of this work at the Center for Biomedical Engineering. E.G. was supported by a fellowship from the Institut Quimíc de Sarrià (IQS).
PY - 2007/2
Y1 - 2007/2
N2 - A plasma process for the surface modification of HA powders has been developed. Acrylic acid and acrylic acid/octadiene plasma deposited films onto HA particles have demonstrated to interact with SBF allowing the calcium dissolution-precipitation mechanism. Therefore, a nanostructured composite between HA and a self-assembling peptide scaffold (RAD16-I) has been developed. The differentiation of mESC in this scaffold has been studied, in order to test the osteogenic capacity of the new composite material. We have observed that the mESC can be iduced to produce Ca salts (mineralization) in a 3D-microenvironment and moreover, this activity can be enhanced by the presence of HA particules into the nanofiber scaffold.
AB - A plasma process for the surface modification of HA powders has been developed. Acrylic acid and acrylic acid/octadiene plasma deposited films onto HA particles have demonstrated to interact with SBF allowing the calcium dissolution-precipitation mechanism. Therefore, a nanostructured composite between HA and a self-assembling peptide scaffold (RAD16-I) has been developed. The differentiation of mESC in this scaffold has been studied, in order to test the osteogenic capacity of the new composite material. We have observed that the mESC can be iduced to produce Ca salts (mineralization) in a 3D-microenvironment and moreover, this activity can be enhanced by the presence of HA particules into the nanofiber scaffold.
KW - Bone tissue engineering
KW - Cartilage
KW - Hydroxyapatite
KW - Nanostructured composite
UR - http://www.scopus.com/inward/record.url?scp=33846874385&partnerID=8YFLogxK
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=pure_univeritat_ramon_llull&SrcAuth=WosAPI&KeyUT=WOS:000245004900012&DestLinkType=FullRecord&DestApp=WOS_CPL
U2 - 10.1016/j.bioeng.2006.05.017
DO - 10.1016/j.bioeng.2006.05.017
M3 - Article
C2 - 16846750
AN - SCOPUS:33846874385
SN - 1389-0344
VL - 24
SP - 75
EP - 80
JO - Biomolecular Engineering
JF - Biomolecular Engineering
IS - 1 SPEC. ISS.
T2 - Symposium on Nano-Structured and Intelligent Bioactive Materials held at the EMRS 2005 Spring Meeting
Y2 - 29 May 2005 through 2 June 2005
ER -