TY - JOUR
T1 - Experience-dependent neuroplasticity in trained musicians modulates the effects of chronic pain on insula-based networks – A resting-state fMRI study
AU - Zamorano, Anna M.
AU - Montoya, Pedro
AU - Cifre, Ignacio
AU - Vuust, Peter
AU - Riquelme, Inmaculada
AU - Kleber, Boris
N1 - Funding Information:
This work was supported by the Spanish Ministry of Science and Innovation and European Regional Development Funds (# PSI2010-19372 , # PSI2013-48260-C3-1 ); the Regional Government of the Balearic Islands and European Regional Development Funds (#BOIB num. 68-07/05/2011) and the Danish National Research Foundation ( DNRF117 ).
Funding Information:
We acknowledge the support provided by the Superior Music Conservatory and the Symphony Orchestra of the Balearic Islands. We also thank Dr. Benjamin Deen and Dr. Kevin Pelphrey for kindly providing us with insula ROIs from their earlier work. We are furthermore grateful to Juan Gea for his help with data acquisition as well as to Dr. Ralf Veit and Dr. Stephanie Kullmann for support with data analyses.
Funding Information:
The data that support the findings of this study are available upon reasonable request from the corresponding author, [AZ]. The data are not publicly available due to legal restrictions, as the containing information could compromise the privacy of research participants.This work was supported by the Spanish Ministry of Science and Innovation and European Regional Development Funds (#PSI2010-19372, #PSI2013-48260-C3-1); the Regional Government of the Balearic Islands and European Regional Development Funds (#BOIB num. 68-07/05/2011) and the Danish National Research Foundation (DNRF117). We acknowledge the support provided by the Superior Music Conservatory and the Symphony Orchestra of the Balearic Islands. We also thank Dr. Benjamin Deen and Dr. Kevin Pelphrey for kindly providing us with insula ROIs from their earlier work. We are furthermore grateful to Juan Gea for his help with data acquisition as well as to Dr. Ralf Veit and Dr. Stephanie Kullmann for support with data analyses.
Publisher Copyright:
© 2019 Elsevier Inc.
PY - 2019/11/15
Y1 - 2019/11/15
N2 - Recent resting-state fMRI studies associated extensive musical training with increased insula-based connectivity in large-scale networks involved in salience, emotion, and higher-order cognitive processes. Similar changes have also been found in chronic pain patients, suggesting that both types of experiences can have comparable effects on insula circuitries. Based on these observations, the current study asked the question whether, and if so in what way, different forms of experience-dependent neuroplasticity may interact. Here we assessed insula-based connectivity during fMRI resting-state between musicians and non-musicians both with and without chronic pain, and correlated the results with clinical pain duration and intensity. As expected, insula connectivity was increased in chronic pain non-musicians relative to healthy non-musicians (with cingulate cortex and supplementary motor area), yet no differences were found between chronic pain non-musicians and healthy musicians. In contrast, musicians with chronic pain showed decreased insula connectivity relative to both healthy musicians (with sensorimotor and memory regions) and chronic pain non-musicians (with the hippocampus, inferior temporal gyrus, and orbitofrontal cortex), as well as lower pain-related inferences with daily activities. Pain duration correlated positively with insula connectivity only in non-musicians, whereas pain intensity exhibited distinct relationships across groups. We conclude that although music-related sensorimotor training and chronic pain, taken in isolation, can lead to increased insula-based connectivity, their combination may lead to higher-order plasticity (metaplasticity) in chronic pain musicians, engaging brain mechanisms that can modulate the consequences of maladaptive experience-dependent neural reorganization (i.e., pain chronification).
AB - Recent resting-state fMRI studies associated extensive musical training with increased insula-based connectivity in large-scale networks involved in salience, emotion, and higher-order cognitive processes. Similar changes have also been found in chronic pain patients, suggesting that both types of experiences can have comparable effects on insula circuitries. Based on these observations, the current study asked the question whether, and if so in what way, different forms of experience-dependent neuroplasticity may interact. Here we assessed insula-based connectivity during fMRI resting-state between musicians and non-musicians both with and without chronic pain, and correlated the results with clinical pain duration and intensity. As expected, insula connectivity was increased in chronic pain non-musicians relative to healthy non-musicians (with cingulate cortex and supplementary motor area), yet no differences were found between chronic pain non-musicians and healthy musicians. In contrast, musicians with chronic pain showed decreased insula connectivity relative to both healthy musicians (with sensorimotor and memory regions) and chronic pain non-musicians (with the hippocampus, inferior temporal gyrus, and orbitofrontal cortex), as well as lower pain-related inferences with daily activities. Pain duration correlated positively with insula connectivity only in non-musicians, whereas pain intensity exhibited distinct relationships across groups. We conclude that although music-related sensorimotor training and chronic pain, taken in isolation, can lead to increased insula-based connectivity, their combination may lead to higher-order plasticity (metaplasticity) in chronic pain musicians, engaging brain mechanisms that can modulate the consequences of maladaptive experience-dependent neural reorganization (i.e., pain chronification).
KW - Chronic pain
KW - Experience-dependent neuroplasticity
KW - Insula
KW - Musicians
KW - Resting-state fMRI
KW - Sensorimotor training
UR - http://www.scopus.com/inward/record.url?scp=85071375545&partnerID=8YFLogxK
U2 - 10.1016/j.neuroimage.2019.116103
DO - 10.1016/j.neuroimage.2019.116103
M3 - Article
C2 - 31437550
AN - SCOPUS:85071375545
SN - 1053-8119
VL - 202
JO - NeuroImage
JF - NeuroImage
M1 - 116103
ER -