Expeditious synthesis of a new hexasaccharide using transglycosylation reaction catalyzed by Bacillus (1→3),(1→4)-β-D-glucan 4-glucanohydrolase

Josep Lluís Viladot, Bruce Stone, Hugues Driguez, Antoni Planas

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Resum

Enzymatic hydrolysis of barley (1→3),(1→4)-β-D-glucan using a recombinant (1→3),(1→4)-β-glucanase from Bacillus licheniformis gives Glcβ4Glcβ3Glc isolated after acetylation in 49% yield. Conventional treatment produced the corresponding β-fluoride which was carefully de-O-acetylated. A transglycosylation reaction with this substrate, catalyzed by the title enzyme, gave Glcβ4Glcβ3Glcβ4Glcβ4Glcβ3Glc in 20% yield. Copyright (C) 1997 Elsevier Science Ltd.

Idioma originalAnglès
Pàgines (de-a)95-99
Nombre de pàgines5
RevistaCarbohydrate Research
Volum311
Número1-2
DOIs
Estat de la publicacióPublicada - de set. 1998

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