Energy balance and risk of mortality in Spanish older adults

Camille Lassale, Álvaro Hernáez, Estefanía Toledo, Olga Castañer, José V. Sorlí, Jordi Salas-Salvadó, Ramon Estruch, Emilio Ros, Ángel M. Alonso-Gómez, José Lapetra, Raquel Cueto, Miquel Fiol, Lluis Serra-Majem, Xavier Pinto, Alfredo Gea, Dolores Corella, Nancy Babio, Montserrat Fitó, Helmut Schröder

Producció científica: Article en revista indexadaArticleAvaluat per experts

3 Cites (Scopus)


Clinical data on the direct health effects of energy deficit or surplus beyond its impact on body weight are scarce. We aimed to assess the association with all-cause, cardiovascular and cancer mortality of (1) sustained energy deficit or surplus, calculated according to each individual’s en-ergy intake (EI) and theoretical energy expenditure (TEE), and (2) mid-term change in total EI in a prospective study. In 7119 participants in the PREDIMED Study (PREvención con DIeta MEDiterránea) with a mean age of 67 years, energy intake was derived from a 137-item food frequency questionnaire. TEE was calculated as a function of age, sex, height, body weight and physical ac-tivity. The main exposure was the proportion of energy requirement covered by energy intake, cumulative throughout the follow-up. The secondary exposure was the change in energy intake from baseline. Cox proportional hazard models were used to estimate hazard ratios and 95% con-fidence intervals for all-cause, cardiovascular and cancer mortality. Over a median follow-up of 4.8 years, there were 239 deaths (excluding the first 2 years). An energy intake exceeding energy needs was associated with an increase in mortality risk (continuous HR10% over energy needs = 1.10; 95% CI 1.02, 1.18), driven by cardiovascular death (HR = 1.26; 95% CI 1.11, 1.43). However, consum-ing energy below estimated needs was not associated with a lower risk. Increments over time in energy intake were associated with greater all-cause mortality (HR10% increase = 1.09; 95% CI 1.02, 1.17). However, there was no evidence that a substantial negative change in energy intake would reduce mortality risk. To conclude, in an older Mediterranean cohort, energy surplus or increase over a 5-year period was associated with greater risk of mortality, particularly cardiovascular mortality. Energy deficit, or reduction in energy intake over time were not associated with mortal-ity risk.

Idioma originalAnglès
Número d’article1545
Estat de la publicacióPublicada - de maig 2021


Navegar pels temes de recerca de 'Energy balance and risk of mortality in Spanish older adults'. Junts formen un fingerprint únic.

Com citar-ho