Enantioselective protonation/diastereoselective reduction with sodium naphthalenide-acetamide; a new synthesis of chiral trans-2-phenylcyclohexanol

Gregorio Asensio, A. Cuenca, P. Gaviña, Mercedes Medio-Simón

Producció científica: Article en revista indexadaArticleAvaluat per experts

21 Cites (Scopus)

Resum

An efficient synthesis of trans-2-phenylcyclohexanol has been achieved by enantioselective protonation of the enolate of 2-phenylcyclohexanone with α-sulfinyl alcohols and subsequent reduction of the chiral ketone by sodium naphthalenide in the presence of acetamide. Interestingly, the chirality source is not consumed in the synthesis of the chiral target.

Idioma originalAnglès
Pàgines (de-a)3939-3940
Nombre de pàgines2
RevistaTetrahedron Letters
Volum40
Número20
DOIs
Estat de la publicacióPublicada - 14 de maig 1999
Publicat externament

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