Elastomeric cardiopatch scaffold for myocardial repair and ventricular support

Juan Carlos Chachques, Nermine Lila, Carolina Soler-Botija, Cristina Martinez-Ramos, Ana Valles, Gwennhael Autret, Marie Cecile Perier, Nicolas Mirochnik, Manuel Monleon-Pradas, Antoni Bayes-Genis, Carlos E. Semino

Producció científica: Article en revista indexadaArticleAvaluat per experts

15 Cites (Scopus)


OBJECTIVES: Prevention of postischaemic ventricular dilatation progressing towards pathological remodelling is necessary to decrease ventricular wall deterioration. Myocardial tissue engineering may play a therapeutic role due to its capacity to replace the extracellular matrix, thereby creating niches for cell homing. In this experimental animal study, a biomimetic cardiopatch was created with elastomeric scaffolds and nanotechnologies. METHODS: In an experimental animal study in 18 sheep, a cardiopatch was created with adipose tissue-derived progenitor cells seeded into an engineered bioimplant consisting of 3-dimensional bioabsorbable polycaprolactone scaffolds filled with a peptide hydrogel (PuraMatrix™). This patch was then transplanted to cover infarcted myocardium. Non-absorbable poly(ethyl) acrylate polymer scaffolds were used as controls. RESULTS: Fifteen sheep were followed with ultrasound scans at 6 months, including echocardiography scans, tissue Doppler and spectral flow analysis and speckle-tracking imaging, which showed a reduction in longitudinal left ventricular deformation in the cardiopatch-treated group. Magnetic resonance imaging (late gadolinium enhancement) showed reduction of infarct size relative to left ventricular mass in the cardiopatch group versus the controls. Histopathological analysis at 6 months showed that the cardiopatch was fully anchored and integrated to the infarct area with minimal fibrosis interface, thereby promoting angiogenesis and migration of adipose tissue-derived progenitor cells to surrounding tissues. CONCLUSIONS: This study shows the feasibility and effectiveness of a cardiopatch grafted onto myocardial infarction scars in an experimental animal model. This treatment decreased fibrosis, limited infarct scar expansion and reduced postischaemic ventricular deformity. A capillary network developed between our scaffold and the heart. The elastomeric cardiopatch seems to have a positive impact on ventricular remodelling and performance in patients with heart failure.

Idioma originalAnglès
Pàgines (de-a)545-555
Nombre de pàgines11
RevistaEuropean Journal of Cardio-thoracic Surgery
Estat de la publicacióPublicada - 1 de març 2020


Navegar pels temes de recerca de 'Elastomeric cardiopatch scaffold for myocardial repair and ventricular support'. Junts formen un fingerprint únic.

Com citar-ho