TY - JOUR
T1 - Efficient system for the preparation of [13N]labeled nitrosamines
AU - Gómez-Vallejo, Vanessa
AU - Kato, Koichi
AU - Hanyu, Masayuki
AU - Minegishi, Katsuyuki
AU - Borrell, José I.
AU - Llop, Jordi
PY - 2009/4/1
Y1 - 2009/4/1
N2 - In the present Letter, a fast and reproducible method for the synthesis of N-[13N]nitrosamines is reported. The labeling strategy is based on trapping [13N]NO2- in an anion exchange resin. The reaction with secondary amines in the presence of Ph3P and Br2 led to the formation of the desired nitrosamines in short reaction times (2 min) with excellent radiochemical conversion (>45%). Final radiotracers were obtained after purification in good radiochemical yields (>30%, decay corrected). Radiochemical purity was above 99% in all cases.
AB - In the present Letter, a fast and reproducible method for the synthesis of N-[13N]nitrosamines is reported. The labeling strategy is based on trapping [13N]NO2- in an anion exchange resin. The reaction with secondary amines in the presence of Ph3P and Br2 led to the formation of the desired nitrosamines in short reaction times (2 min) with excellent radiochemical conversion (>45%). Final radiotracers were obtained after purification in good radiochemical yields (>30%, decay corrected). Radiochemical purity was above 99% in all cases.
KW - Nitrogen-13
KW - Nitrosamines
KW - Positron emission tomography
UR - http://www.scopus.com/inward/record.url?scp=62149116512&partnerID=8YFLogxK
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=pure_univeritat_ramon_llull&SrcAuth=WosAPI&KeyUT=WOS:000264169700016&DestLinkType=FullRecord&DestApp=WOS
U2 - 10.1016/j.bmcl.2009.02.066
DO - 10.1016/j.bmcl.2009.02.066
M3 - Article
C2 - 19269176
AN - SCOPUS:62149116512
SN - 0960-894X
VL - 19
SP - 1913
EP - 1915
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 7
ER -