Efficient system for the preparation of [13N]labeled nitrosamines

Vanessa Gómez-Vallejo, Koichi Kato, Masayuki Hanyu, Katsuyuki Minegishi, José I. Borrell, Jordi Llop

Producció científica: Article en revista indexadaArticleAvaluat per experts

13 Cites (Scopus)


In the present Letter, a fast and reproducible method for the synthesis of N-[13N]nitrosamines is reported. The labeling strategy is based on trapping [13N]NO2- in an anion exchange resin. The reaction with secondary amines in the presence of Ph3P and Br2 led to the formation of the desired nitrosamines in short reaction times (2 min) with excellent radiochemical conversion (>45%). Final radiotracers were obtained after purification in good radiochemical yields (>30%, decay corrected). Radiochemical purity was above 99% in all cases.

Idioma originalAnglès
Pàgines (de-a)1913-1915
Nombre de pàgines3
RevistaBioorganic and Medicinal Chemistry Letters
Estat de la publicacióPublicada - 1 d’abr. 2009


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