Efficient system for the preparation of [13N]labeled nitrosamines

Vanessa Gómez-Vallejo; Koichi Kato; Masayuki Hanyu; Katsuyuki Minegishi; José I. Borrell; Jordi Llop

doi:10.1016/j.bmcl.2009.02.066

Efficient system for the preparation of [¹³N]labeled nitrosamines

Vanessa Gómez-Vallejo, Koichi Kato, Masayuki Hanyu, Katsuyuki Minegishi, José I. Borrell, Jordi Llop

Producció científica: Article en revista indexada › Article › Avaluat per experts

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Resum

In the present Letter, a fast and reproducible method for the synthesis of N-[¹³N]nitrosamines is reported. The labeling strategy is based on trapping [¹³N]NO₂^- in an anion exchange resin. The reaction with secondary amines in the presence of Ph₃P and Br₂ led to the formation of the desired nitrosamines in short reaction times (2 min) with excellent radiochemical conversion (>45%). Final radiotracers were obtained after purification in good radiochemical yields (>30%, decay corrected). Radiochemical purity was above 99% in all cases.

Idioma original	Anglès
Pàgines (de-a)	1913-1915
Nombre de pàgines	3
Revista	Bioorganic and Medicinal Chemistry Letters
Volum	19
Número	7
DOIs	https://doi.org/10.1016/j.bmcl.2009.02.066
Estat de la publicació	Publicada - 1 d’abr. 2009

Accés al document

10.1016/j.bmcl.2009.02.066

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title = "Efficient system for the preparation of [13N]labeled nitrosamines",

abstract = "In the present Letter, a fast and reproducible method for the synthesis of N-[13N]nitrosamines is reported. The labeling strategy is based on trapping [13N]NO2- in an anion exchange resin. The reaction with secondary amines in the presence of Ph3P and Br2 led to the formation of the desired nitrosamines in short reaction times (2 min) with excellent radiochemical conversion (>45%). Final radiotracers were obtained after purification in good radiochemical yields (>30%, decay corrected). Radiochemical purity was above 99% in all cases.",

keywords = "Nitrogen-13, Nitrosamines, Positron emission tomography",

author = "Vanessa G{\'o}mez-Vallejo and Koichi Kato and Masayuki Hanyu and Katsuyuki Minegishi and Borrell, {Jos{\'e} I.} and Jordi Llop",

note = "Funding Information: The authors would like to thank Dr. Fujiko Konno, the staff of cyclotron section and personnel of the department of molecular probes of National Institute of Radiological Sciences for helping throughout experimental work. We also thank the Departamento de Industria, Comercio y Turismo of the Vasc Government for financial support.",

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T1 - Efficient system for the preparation of [13N]labeled nitrosamines

AU - Gómez-Vallejo, Vanessa

AU - Kato, Koichi

AU - Hanyu, Masayuki

AU - Minegishi, Katsuyuki

AU - Borrell, José I.

AU - Llop, Jordi

N1 - Funding Information: The authors would like to thank Dr. Fujiko Konno, the staff of cyclotron section and personnel of the department of molecular probes of National Institute of Radiological Sciences for helping throughout experimental work. We also thank the Departamento de Industria, Comercio y Turismo of the Vasc Government for financial support.

PY - 2009/4/1

Y1 - 2009/4/1

N2 - In the present Letter, a fast and reproducible method for the synthesis of N-[13N]nitrosamines is reported. The labeling strategy is based on trapping [13N]NO2- in an anion exchange resin. The reaction with secondary amines in the presence of Ph3P and Br2 led to the formation of the desired nitrosamines in short reaction times (2 min) with excellent radiochemical conversion (>45%). Final radiotracers were obtained after purification in good radiochemical yields (>30%, decay corrected). Radiochemical purity was above 99% in all cases.

AB - In the present Letter, a fast and reproducible method for the synthesis of N-[13N]nitrosamines is reported. The labeling strategy is based on trapping [13N]NO2- in an anion exchange resin. The reaction with secondary amines in the presence of Ph3P and Br2 led to the formation of the desired nitrosamines in short reaction times (2 min) with excellent radiochemical conversion (>45%). Final radiotracers were obtained after purification in good radiochemical yields (>30%, decay corrected). Radiochemical purity was above 99% in all cases.

KW - Nitrogen-13

KW - Nitrosamines

KW - Positron emission tomography

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