Resum
Dietary polyphenol intake is associated with improvement of metabolic disturbances. The aims of the present study are to describe dietary polyphenol intake in a population with metabolic syndrome (MetS) and to examine the association between polyphenol intake and the components of MetS. This cross-sectional analysis involved 6633 men and women included in the PREDIMED (PREvención con DIeta MEDiterranea-Plus) study. The polyphenol content of foods was estimated from the Phenol-Explorer 3.6 database. The mean of total polyphenol intake was 846 ± 318 mg/day. Except for stilbenes, women had higher polyphenol intake than men. Total polyphenol intake was higher in older participants (>70 years of age) compared to their younger counterparts. Participants with body mass index (BMI) >35 kg/m2 reported lower total polyphenol, flavonoid, and stilbene intake than those with lower BMI. Total polyphenol intake was not associated with a better profile concerning MetS components, except for high-density lipoprotein cholesterol (HDL-c), although stilbenes, lignans, and other polyphenols showed an inverse association with blood pressure, fasting plasma glucose, and triglycerides. A direct association with HDL-c was found for all subclasses except lignans and phenolic acids. To conclude, in participants with MetS, higher intake of several polyphenol subclasses was associated with a better profile of MetS components, especially HDL-c.
| Idioma original | Anglès |
|---|---|
| Número d’article | 689 |
| Revista | Nutrients |
| Volum | 12 |
| Número | 3 |
| DOIs | |
| Estat de la publicació | Publicada - de març 2020 |
| Publicat externament | Sí |
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In: Nutrients, Vol. 12, Núm. 3, 689, 03.2020.
Producció científica: Article en revista indexada › Article › Avaluat per experts
TY - JOUR
T1 - Dietary polyphenol intake is associated with HDL-cholesterol and a better profile of other components of the metabolic syndrome
T2 - A PREDIMED-plus sub-study
AU - Castro-Barquero, Sara
AU - Tresserra-Rimbau, Anna
AU - Vitelli-Storelli, Facundo
AU - Doménech, Mónica
AU - Salas-Salvadó, Jordi
AU - Martín-Sánchez, Vicente
AU - Rubín-García, María
AU - Buil-Cosiales, Pilar
AU - Corella, Dolores
AU - Fitó, Montserrat
AU - Romaguera, Dora
AU - Vioque, Jesús
AU - Alonso-Gómez, Ángel María
AU - Wärnberg, Julia
AU - Martínez, José Alfredo
AU - Serra-Majem, Luís
AU - Tinahones, Francisco José
AU - Lapetra, José
AU - Pintó, Xavier
AU - Tur, Josep Antonio
AU - Garcia-Rios, Antonio
AU - García-Molina, Laura
AU - Delgado-Rodriguez, Miguel
AU - Matía-Martín, Pilar
AU - Daimiel, Lidia
AU - Vidal, Josep
AU - Vázquez, Clotilde
AU - Cofán, Montserrat
AU - Romanos-Nanclares, Andrea
AU - Becerra-Tomas, Nerea
AU - Barragan, Rocio
AU - Castañer, Olga
AU - Konieczna, Jadwiga
AU - González-Palacios, Sandra
AU - Sorto-Sánchez, Carolina
AU - Pérez-López, Jessica
AU - Zulet, María Angeles
AU - Bautista-Castaño, Inmaculada
AU - Casas, Rosa
AU - Gómez-Perez, Ana María
AU - Santos-Lozano, José Manuel
AU - Rodríguez-Sanchez, María Ángeles
AU - Julibert, Alicia
AU - Martín-Calvo, Nerea
AU - Hernández-Alonso, Pablo
AU - Sorlí, José V.
AU - Sanllorente, Albert
AU - Galmés-Panadés, Aina María
AU - Cases-Pérez, Eugenio
AU - Goicolea-Güemez, Leire
AU - Ruiz-Canela, Miguel
AU - Babio, Nancy
AU - Hernáez, Álvaro
AU - Lamuela-Raventós, Rosa María
AU - Estruch, Ramon
N1 - Funding Information: Funding: The PREDIMED-Plus trial was supported by official Spanish institutions for funding scientific biomedical research, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn) and Instituto de Salud Carlos III (ISCIII), through the Fondo de Investigación para la Salud (FIS), which is co-funded by the European Regional Development Fund (four coordinated FIS projects led by J.S.-S. and J.Vi., including the following projects: PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI14/00972, PI14/00728, PI14/01471, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732, and PI17/00926), the Special Action Project entitled: Implementación y evaluación de una intervención intensiva sobre la actividad física Cohorte PREDIMED-Plus grant to J.S.-S., the Recercaixa grant to J.S.-S. (2013ACUP00194), a grant from the Fundació la Marató de TV3 (PI044003), grants from the Consejería de Salud de la Junta de Andalucía (PI0458/2013, PS0358/2016, and PI0137/2018),grants from the Generalitat Valenciana (PROMETEO/2017/017, APOSTD/2019/136), a SEMERGEN grant, a CICYT grant provided by the Ministerio de Ciencia, Innovación y Universidades (AGL2016-75329-R) and funds from the European Regional Development Fund (CB06/03). The Spanish Ministry of Science Innovation and Universities for the Formación de Profesorado Universitario (FPU17/00785) contract. Food companies Hojiblanca (Lucena, Spain) and Patrimonio Comunal Olivarero (Madrid, Spain) donated extra virgin olive oil, and the Almond Board of California (Modesto, CA), American Pistachio Growers (Fresno, CA), and Paramount Farms (Wonderful Company, LLC, Los Angeles, CA) donated nuts. This call is co-financed at 50% with charge to the Operational Program FSE 2014-2020 of the Balearic Islands. Funding Information: Acknowledgments: We thank all the volunteers for their participation and medical professionals for their contribution to the PREDIMED-Plus trial. CIBEROBN, CIBERESP, and CIBERDEM are initiatives of the Instituto de Salud Carlos III (ISCIII), Madrid, Spain. A.T.R. and P.H.A. thanks the Ministry of Science Innovation and Universities for the Juan de la Cierva-formación contract. J.K. is grateful to the Fundación Instituto de Investigación Sanitaria Illes Balears (call financed by 2017annual plan of the sustainable tourism tax and at 50% with charge to the ESF Operational Program 2014–2020 of the Balearic Islands) for the postdoctoral contract for the ‘FOLIUM’ programme within the FUTURMed. Funding Information: The PREDIMED-Plus trial was supported by official Spanish institutions for funding scientific biomedical research, CIBER Fisiopatolog?a de la Obesidad y Nutrici?n (CIBERobn) and Instituto de Salud Carlos III (ISCIII), through the Fondo de Investigaci?n para la Salud (FIS), which is co-funded by the European Regional Development Fund (four coordinated FIS projects led by J.S.-S. and J.Vi., including the following projects: PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI14/00972, PI14/00728, PI14/01471, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732, and PI17/00926), the Special Action Project entitled: Implementaci?n y evaluaci?n de una intervenci?n intensiva sobre la actividad f?sica Cohorte PREDIMED-Plus grant to J.S.-S., the Recercaixa grant to J.S.-S. (2013ACUP00194), a grant from the Fundaci? la Marat? de TV3 (PI044003), grants from the Consejer?a de Salud de la Junta de Andaluc?a (PI0458/2013, PS0358/2016, and PI0137/2018),grants from the Generalitat Valenciana (PROMETEO/2017/017, APOSTD/2019/136), a SEMERGEN grant, a CICYT grant provided by the Ministerio de Ciencia, Innovaci?n y Universidades (AGL2016-75329-R) and funds from the European Regional Development Fund (CB06/03). The Spanish Ministry of Science Innovation and Universities for the Formaci?n de Profesorado Universitario (FPU17/00785) contract. Food companies Hojiblanca (Lucena, Spain) and Patrimonio Comunal Olivarero (Madrid, Spain) donated extra virgin olive oil, and the Almond Board of California (Modesto, CA), American Pistachio Growers (Fresno, CA), and Paramount Farms (Wonderful Company, LLC, Los Angeles, CA) donated nuts. This call is co-financed at 50% with charge to the Operational Program FSE 2014-2020 of the Balearic Islands. Funding Information: Conflicts of Interest: R.E. reported receiving grants from Instituto de Salud Carlos III and olive oil for the trial from Fundacion Patrimonio Comunal Olivarero during the conduct of the study and personal fees from Brewers of Europe, Fundación Cerveza y Salud, Interprofesional del Aceite de Oliva, Instituto Cervantes, Instituto Cervantes, Pernaud Richar, Fundación Dieta Mediterránea, Wine and Culinary International Forum; nonfinancial support from Sociedad Española de Nutrición and Fundación Bosch y Gimpera; and grants from Uriach Laboratories outside the submitted work.. R.M.L.-R. reports personal fees from Cerveceros de España, personal fees and other from Adventia, other from Ecoveritas, S.A., outside the submitted work. The rest of authors have no conflict of interest. None of the funding sources took part in the design, collection, analysis, or interpretation of the data or in the decision to submit the manuscript for publication. Publisher Copyright: © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2020/3
Y1 - 2020/3
N2 - Dietary polyphenol intake is associated with improvement of metabolic disturbances. The aims of the present study are to describe dietary polyphenol intake in a population with metabolic syndrome (MetS) and to examine the association between polyphenol intake and the components of MetS. This cross-sectional analysis involved 6633 men and women included in the PREDIMED (PREvención con DIeta MEDiterranea-Plus) study. The polyphenol content of foods was estimated from the Phenol-Explorer 3.6 database. The mean of total polyphenol intake was 846 ± 318 mg/day. Except for stilbenes, women had higher polyphenol intake than men. Total polyphenol intake was higher in older participants (>70 years of age) compared to their younger counterparts. Participants with body mass index (BMI) >35 kg/m2 reported lower total polyphenol, flavonoid, and stilbene intake than those with lower BMI. Total polyphenol intake was not associated with a better profile concerning MetS components, except for high-density lipoprotein cholesterol (HDL-c), although stilbenes, lignans, and other polyphenols showed an inverse association with blood pressure, fasting plasma glucose, and triglycerides. A direct association with HDL-c was found for all subclasses except lignans and phenolic acids. To conclude, in participants with MetS, higher intake of several polyphenol subclasses was associated with a better profile of MetS components, especially HDL-c.
AB - Dietary polyphenol intake is associated with improvement of metabolic disturbances. The aims of the present study are to describe dietary polyphenol intake in a population with metabolic syndrome (MetS) and to examine the association between polyphenol intake and the components of MetS. This cross-sectional analysis involved 6633 men and women included in the PREDIMED (PREvención con DIeta MEDiterranea-Plus) study. The polyphenol content of foods was estimated from the Phenol-Explorer 3.6 database. The mean of total polyphenol intake was 846 ± 318 mg/day. Except for stilbenes, women had higher polyphenol intake than men. Total polyphenol intake was higher in older participants (>70 years of age) compared to their younger counterparts. Participants with body mass index (BMI) >35 kg/m2 reported lower total polyphenol, flavonoid, and stilbene intake than those with lower BMI. Total polyphenol intake was not associated with a better profile concerning MetS components, except for high-density lipoprotein cholesterol (HDL-c), although stilbenes, lignans, and other polyphenols showed an inverse association with blood pressure, fasting plasma glucose, and triglycerides. A direct association with HDL-c was found for all subclasses except lignans and phenolic acids. To conclude, in participants with MetS, higher intake of several polyphenol subclasses was associated with a better profile of MetS components, especially HDL-c.
KW - Glignans
KW - HDL-cholesterol
KW - Mediterranean diet
KW - Metabolic syndrome
KW - Polyphenols
KW - Stilbenes
UR - http://www.scopus.com/inward/record.url?scp=85080972652&partnerID=8YFLogxK
U2 - 10.3390/nu12030689
DO - 10.3390/nu12030689
M3 - Article
C2 - 32143308
AN - SCOPUS:85080972652
SN - 2072-6643
VL - 12
JO - Nutrients
JF - Nutrients
IS - 3
M1 - 689
ER -