Resum
Among the known non-benzodiazepinic hypnotic drugs acting on the α1 subunit of the GABA-A receptor, Zolpidem (2a), Zaleplon (1b) and Indiplon (1a) have showed high affinity and selectivity. Following a design methodology including pharmacophoric requirements and ADME-predicted properties, we have synthesized a library of 3-amino-4,5-dihydro-1H-pyrazolo[3,4-b]pyridin-6(7H)- ones (3) and their N1-alkyl derivatives (4) as new scaffolds for designing non-benzodiazepine BZ receptor ligands.
Idioma original | Anglès |
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Pàgines (de-a) | 1179-1187 |
Nombre de pàgines | 9 |
Revista | European Journal of Medicinal Chemistry |
Volum | 40 |
Número | 11 |
DOIs | |
Estat de la publicació | Publicada - de nov. 2005 |