Design and synthesis of two pyrazole libraries based on o-hydroxyacetophenones

José I. Borrell, Elisabeth Schuler, Jordi Teixidó, Enrique L. Michelotti

Producció científica: Article en revista indexadaArticleAvaluat per experts

4 Cites (Scopus)


Two new solid-phase syntheses of substituted pyrazoles are described. The first includes supporting an o-hydroxyacetophenone on Merrifield resin, Vilsmeier-Haack formylation on the methyl group and cyclization with a substituted hydrazine to afford a pyrazole ring with two diversity centers. The second starts from o-hydroxyacetophenone supported on Wang resin, which undergoes a Claisen condensation with a carboxylic acid ester to yield a 1,3-dicarbonyl compound that cyclizes to a pyrazole using a hydrazine. Both methods have been used to synthesize two small pyrazole libraries.

Idioma originalAnglès
Pàgines (de-a)147-157
Nombre de pàgines11
RevistaMolecular Diversity
Estat de la publicacióPublicada - 2004


Navegar pels temes de recerca de 'Design and synthesis of two pyrazole libraries based on o-hydroxyacetophenones'. Junts formen un fingerprint únic.

Com citar-ho