Design and preclinical evaluation of a first-in-class covalent reversible inhibitor of IRAK4 with immunomodulatory properties and selective anti-lymphoma effect

Gema Gorjon de Pablo; Nuria Profitos-Peleja; Miek Jacobs; Aitor Gonzalez-Herrero; Jeronimo Parra; Elisabetta Mereu; Paula Cifuentes; Melissa Orphali; Jordi Teixidó Closa; Manel Esteller; Jose I. Borrell; Roger Estrada-Tejedor; Gael Roue

doi:10.1158/1538-7445.AM2025-6160

Design and preclinical evaluation of a first-in-class covalent reversible inhibitor of IRAK4 with immunomodulatory properties and selective anti-lymphoma effect

Gema Gorjon de Pablo, Nuria Profitos-Peleja, Miek Jacobs, Aitor Gonzalez-Herrero, Jeronimo Parra, Elisabetta Mereu, Paula Cifuentes, Melissa Orphali, Jordi Teixidó Closa, Manel Esteller, Jose I. Borrell, Roger Estrada-Tejedor, Gael Roue

Producció científica: Article en revista indexada › Resum de jornada › Avaluat per experts

Idioma original	Anglès
Nombre de pàgines	2
Revista	Cancer Research
Volum	85
Número	8
DOIs	https://doi.org/10.1158/1538-7445.AM2025-6160
Estat de la publicació	Publicada - 15 d’abr. 2025
Esdeveniment	Annual Meeting of the American-Association-for-Cancer-Research (AACR) - Chicago, Israel Durada: 25 d’abr. 2025 → 30 d’abr. 2025

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10.1158/1538-7445.AM2025-6160

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de Pablo, G. G., Profitos-Peleja, N., Jacobs, M., Gonzalez-Herrero, A., Parra, J., Mereu, E., Cifuentes, P., Orphali, M., Teixidó Closa, J., Esteller, M., Borrell, J. I., Estrada-Tejedor, R., & Roue, G. (2025). Design and preclinical evaluation of a first-in-class covalent reversible inhibitor of IRAK4 with immunomodulatory properties and selective anti-lymphoma effect. Cancer Research, 85(8). https://doi.org/10.1158/1538-7445.AM2025-6160

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title = "Design and preclinical evaluation of a first-in-class covalent reversible inhibitor of IRAK4 with immunomodulatory properties and selective anti-lymphoma effect",

author = "\{de Pablo\}, \{Gema Gorjon\} and Nuria Profitos-Peleja and Miek Jacobs and Aitor Gonzalez-Herrero and Jeronimo Parra and Elisabetta Mereu and Paula Cifuentes and Melissa Orphali and \{Teixid{\'o} Closa\}, Jordi and Manel Esteller and Borrell, \{Jose I.\} and Roger Estrada-Tejedor and Gael Roue",

year = "2025",

month = apr,

day = "15",

doi = "10.1158/1538-7445.AM2025-6160",

language = "English",

volume = "85",

journal = "Cancer Research",

issn = "0008-5472",

publisher = "American Association for Cancer Research Inc.",

number = "8",

note = "Annual Meeting of the American-Association-for-Cancer-Research (AACR) ; Conference date: 25-04-2025 Through 30-04-2025",

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de Pablo, GG, Profitos-Peleja, N, Jacobs, M, Gonzalez-Herrero, A, Parra, J, Mereu, E, Cifuentes, P, Orphali, M, Teixidó Closa, J, Esteller, M, Borrell, JI , Estrada-Tejedor, R & Roue, G 2025, 'Design and preclinical evaluation of a first-in-class covalent reversible inhibitor of IRAK4 with immunomodulatory properties and selective anti-lymphoma effect', Cancer Research, vol. 85, núm. 8. https://doi.org/10.1158/1538-7445.AM2025-6160

Design and preclinical evaluation of a first-in-class covalent reversible inhibitor of IRAK4 with immunomodulatory properties and selective anti-lymphoma effect. / de Pablo, Gema Gorjon; Profitos-Peleja, Nuria; Jacobs, Miek et al.
In: Cancer Research, Vol. 85, Núm. 8, 15.04.2025.

Producció científica: Article en revista indexada › Resum de jornada › Avaluat per experts

TY - JOUR

T1 - Design and preclinical evaluation of a first-in-class covalent reversible inhibitor of IRAK4 with immunomodulatory properties and selective anti-lymphoma effect

AU - de Pablo, Gema Gorjon

AU - Profitos-Peleja, Nuria

AU - Jacobs, Miek

AU - Gonzalez-Herrero, Aitor

AU - Parra, Jeronimo

AU - Mereu, Elisabetta

AU - Cifuentes, Paula

AU - Orphali, Melissa

AU - Teixidó Closa, Jordi

AU - Esteller, Manel

AU - Borrell, Jose I.

AU - Estrada-Tejedor, Roger

AU - Roue, Gael

PY - 2025/4/15

Y1 - 2025/4/15

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U2 - 10.1158/1538-7445.AM2025-6160

DO - 10.1158/1538-7445.AM2025-6160

M3 - Meeting Abstract

SN - 0008-5472

VL - 85

JO - Cancer Research

JF - Cancer Research

IS - 8

T2 - Annual Meeting of the American-Association-for-Cancer-Research (AACR)

Y2 - 25 April 2025 through 30 April 2025

ER -