TY - JOUR
T1 - Current progress in bionanomaterials to modulate the epigenome
AU - Rhodes, Anna D.Y.
AU - Duran-Mota, Jose Antonio
AU - Oliva, Nuria
N1 - Publisher Copyright:
© 2022 The Royal Society of Chemistry.
PY - 2022/7/21
Y1 - 2022/7/21
N2 - Recent advances in genomics during the 1990s have made it possible to study and identify genetic and epigenetic responses of cells and tissues to various drugs and environmental factors. This has accelerated the number of targets available to treat a range of diseases from cancer to wound healing disorders. Equally interesting is the understanding of how bio- and nanomaterials alter gene expression through epigenetic mechanisms, and whether they have the potential to elicit a positive therapeutic response without requiring additional biomolecule delivery. In fact, from a cell's perspective, a biomaterial is nothing more than an environmental factor, and so it has the power to epigenetically modulate gene expression of cells in contact with it. Understanding these epigenetic interactions between biomaterials and cells will open new avenues in the development of technologies that can not only provide biological signals (i.e. drugs, growth factors) necessary for therapy and regeneration, but also intimately interact with cells to promote the expression of genes of interest. This review article aims to summarise the current state-of-the-art and progress on the development of bio- and nanomaterials to modulate the epigenome.
AB - Recent advances in genomics during the 1990s have made it possible to study and identify genetic and epigenetic responses of cells and tissues to various drugs and environmental factors. This has accelerated the number of targets available to treat a range of diseases from cancer to wound healing disorders. Equally interesting is the understanding of how bio- and nanomaterials alter gene expression through epigenetic mechanisms, and whether they have the potential to elicit a positive therapeutic response without requiring additional biomolecule delivery. In fact, from a cell's perspective, a biomaterial is nothing more than an environmental factor, and so it has the power to epigenetically modulate gene expression of cells in contact with it. Understanding these epigenetic interactions between biomaterials and cells will open new avenues in the development of technologies that can not only provide biological signals (i.e. drugs, growth factors) necessary for therapy and regeneration, but also intimately interact with cells to promote the expression of genes of interest. This review article aims to summarise the current state-of-the-art and progress on the development of bio- and nanomaterials to modulate the epigenome.
UR - http://www.scopus.com/inward/record.url?scp=85135363250&partnerID=8YFLogxK
UR - http://hdl.handle.net/20.500.14342/4451
U2 - 10.1039/d2bm01027e
DO - 10.1039/d2bm01027e
M3 - Review
C2 - 35880652
AN - SCOPUS:85135363250
SN - 2047-4830
VL - 10
SP - 5081
EP - 5091
JO - Biomaterials Science
JF - Biomaterials Science
IS - 18
ER -