TY - JOUR
T1 - Creating the bioartificial myocardium for cardiac repair
T2 - Challenges and clinical targets
AU - Chachques, Juan C.
AU - Pradas, Manuel Monleon
AU - Bayes-Genis, Antoni
AU - Semino, Carlos
PY - 2013
Y1 - 2013
N2 - The association of stem cells with tissue-engineered scaffolds constitutes an attractive approach for the repair of myocardial tissue with positive effects to avoid ventricular chamber dilatation, which changes from a natural elliptical to spherical shape in heart failure patients. Biohybrid scaffolds using nanomaterials combined with stem cells emerge as new therapeutic tool for the creation of 'bioartificial myocardium' and 'cardiac wrap bioprostheses' for myocardial regeneration and ventricular support. Biohybrids are created introducing stem cells and self-assembling peptide nanofibers inside a porous elastomeric membrane, forming cell niches. Our studies lead to the creation of semi-degradable 'ventricular support bioprostheses' for adaptative LV and/or RV wrapping, designed with the concept of 'helical myocardial bands'. The goal is to restore LV elliptical shape, and contribute to systolic contraction and diastolic filling (suction mechanism). Cardiac wrapping with ventricular bioprostheses may reduce the risk of heart failure progression and the indication for heart transplantation.
AB - The association of stem cells with tissue-engineered scaffolds constitutes an attractive approach for the repair of myocardial tissue with positive effects to avoid ventricular chamber dilatation, which changes from a natural elliptical to spherical shape in heart failure patients. Biohybrid scaffolds using nanomaterials combined with stem cells emerge as new therapeutic tool for the creation of 'bioartificial myocardium' and 'cardiac wrap bioprostheses' for myocardial regeneration and ventricular support. Biohybrids are created introducing stem cells and self-assembling peptide nanofibers inside a porous elastomeric membrane, forming cell niches. Our studies lead to the creation of semi-degradable 'ventricular support bioprostheses' for adaptative LV and/or RV wrapping, designed with the concept of 'helical myocardial bands'. The goal is to restore LV elliptical shape, and contribute to systolic contraction and diastolic filling (suction mechanism). Cardiac wrapping with ventricular bioprostheses may reduce the risk of heart failure progression and the indication for heart transplantation.
KW - Bioartificial myocardium
KW - Biohybrid scaffolds
KW - Bionanomaterials
KW - Cardiac bioregeneration
KW - Cardiomyoplasty
KW - Cell transplantation
KW - Heart failure
KW - Myocardial infarction
KW - Myocardial regeneration
KW - Tissue engineering
UR - http://www.scopus.com/inward/record.url?scp=84888046327&partnerID=8YFLogxK
U2 - 10.1586/14779072.2013.854165
DO - 10.1586/14779072.2013.854165
M3 - Review
C2 - 24215199
AN - SCOPUS:84888046327
SN - 1477-9072
VL - 11
SP - 1701
EP - 1711
JO - Expert Review of Cardiovascular Therapy
JF - Expert Review of Cardiovascular Therapy
IS - 12
ER -