TY - JOUR
T1 - COVID-19
T2 - Drug Targets and Potential Treatments
AU - Gil, Carmen
AU - Ginex, Tiziana
AU - Maestro, Inés
AU - Nozal, Vanesa
AU - Barrado-Gil, Lucía
AU - Cuesta-Geijo, Miguel Ángel
AU - Urquiza, Jesús
AU - Ramírez, David
AU - Alonso, Covadonga
AU - Campillo, Nuria E.
AU - Martinez, Ana
N1 - Publisher Copyright:
© 2020 American Chemical Society. All rights reserved.
PY - 2020/11/12
Y1 - 2020/11/12
N2 - Currently, humans are immersed in a pandemic caused by the emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which threatens public health worldwide. To date, no drug or vaccine has been approved to treat the severe disease caused by this coronavirus, COVID-19. In this paper, we will focus on the main virus-based and host-based targets that can guide efforts in medicinal chemistry to discover new drugs for this devastating disease. In principle, all CoV enzymes and proteins involved in viral replication and the control of host cellular machineries are potentially druggable targets in the search for therapeutic options for SARS-CoV-2. This Perspective provides an overview of the main targets from a structural point of view, together with reported therapeutic compounds with activity against SARS-CoV-2 and/or other CoVs. Also, the role of innate immune response to coronavirus infection and the related therapeutic options will be presented.
AB - Currently, humans are immersed in a pandemic caused by the emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which threatens public health worldwide. To date, no drug or vaccine has been approved to treat the severe disease caused by this coronavirus, COVID-19. In this paper, we will focus on the main virus-based and host-based targets that can guide efforts in medicinal chemistry to discover new drugs for this devastating disease. In principle, all CoV enzymes and proteins involved in viral replication and the control of host cellular machineries are potentially druggable targets in the search for therapeutic options for SARS-CoV-2. This Perspective provides an overview of the main targets from a structural point of view, together with reported therapeutic compounds with activity against SARS-CoV-2 and/or other CoVs. Also, the role of innate immune response to coronavirus infection and the related therapeutic options will be presented.
UR - https://www.scopus.com/pages/publications/85088043154
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=pure_univeritat_ramon_llull&SrcAuth=WosAPI&KeyUT=WOS:000592734300012&DestLinkType=FullRecord&DestApp=WOS_CPL
U2 - 10.1021/acs.jmedchem.0c00606
DO - 10.1021/acs.jmedchem.0c00606
M3 - Review
C2 - 32511912
AN - SCOPUS:85088043154
SN - 0022-2623
VL - 63
SP - 12359
EP - 12386
JO - Journal of Medicinal Chemistry
JF - Journal of Medicinal Chemistry
IS - 21
ER -
