Contralateral dissociation between neural activity and cerebral blood volume during recurrent acute focal neocortical seizures

Sam Harris*, Luke Boorman, Michael Bruyns-Haylett, Aneurin Kennerley, Hongtao Ma, Mingrui Zhao, Paul G. Overton, Theodore H. Schwartz, Jason Berwick

*Autor corresponent d’aquest treball

Producció científica: Article en revista indexadaArticleAvaluat per experts

18 Cites (Scopus)

Resum

Objective: Whether epileptic events disrupt normal neurovascular coupling mechanisms locally or remotely is unclear. We sought to investigate neurovascular coupling in an acute model of focal neocortical epilepsy, both within the seizure onset zone and in contralateral homotopic cortex.

Methods: Neurovascular coupling in both ipsilateral and contralateral vibrissal cortices of the urethane-anesthetized rat were examined during recurrent 4-aminopyridine (4-AP, 15 mM, 1 μl) induced focal seizures. Local field potential (LFP) and multiunit spiking activity (MUA) were recorded via two bilaterally implanted 16-channel microelectrodes. Concurrent two-dimensional optical imaging spectroscopy was used to produce spatiotemporal maps of cerebral blood volume (CBV).

Results: Recurrent acute seizures in right vibrissal cortex (RVC) produced robust ipsilateral increases in LFP and MUA activity, most prominently in layer 5, that were nonlinearly correlated to local increases in CBV. In contrast, contralateral left vibrissal cortex (LVC) exhibited relatively smaller nonlaminar specific increases in neural activity coupled with a decrease in CBV, suggestive of dissociation between neural and hemodynamic responses.

Significance: These findings provide insights into the impact of epileptic events on the neurovascular unit, and have important implications both for the interpretation of perfusion-based imaging signals in the disorder and understanding the widespread effects of epilepsy.

Idioma originalAnglès
Pàgines (de-a)1423-1430
Nombre de pàgines8
RevistaEpilepsia
Volum55
Número9
DOIs
Estat de la publicacióPublicada - de set. 2014
Publicat externament

Fingerprint

Navegar pels temes de recerca de 'Contralateral dissociation between neural activity and cerebral blood volume during recurrent acute focal neocortical seizures'. Junts formen un fingerprint únic.

Com citar-ho