TY - JOUR
T1 - Consumption of meat and dairy and lymphoma risk in the European Prospective Investigation into Cancer and Nutrition
AU - Rohrmann, Sabine
AU - Linseisen, Jakob
AU - Jakobsen, Marianne Uhre
AU - Overvad, Kim
AU - Raaschou-Nielsen, Ole
AU - Tjonneland, Anne
AU - Boutron-Ruault, Marie Christine
AU - Kaaks, Rudolf
AU - Becker, Nikolaus
AU - Bergmann, Manuela
AU - Boeing, Heiner
AU - Khaw, Kay Tee
AU - Wareham, Nicholas J.
AU - Key, Timothy J.
AU - Travis, Ruth
AU - Benetou, Vassiliki
AU - Naska, Androniki
AU - Trichopoulou, Antonia
AU - Pala, Valeria
AU - Tumino, Rosario
AU - Masala, Giovanna
AU - Mattiello, Amalia
AU - Brustad, Magritt
AU - Lund, Eiliv
AU - Skeie, Guri
AU - Bueno-De-Mesquita, H. Bas
AU - Peeters, Petra H.M.
AU - Vermeulen, Roel C.H.
AU - Jakszyn, Paula
AU - Dorronsoro, Miren
AU - Barricarte, Aurelio
AU - Tormo, Maria Jose
AU - Molina, Esther
AU - Argüelles, Marcial
AU - Melin, Beatrice
AU - Ericson, Ulrika
AU - Manjer, Jonas
AU - Rinaldi, Sabina
AU - Slimani, Nadia
AU - Boffetta, Paolo
AU - Vergnaud, Anne Claire
AU - Khan, Aneire
AU - Norat, Teresa
AU - Vineis, Paolo
PY - 2011/2/1
Y1 - 2011/2/1
N2 - The consumption of meat and other foods of animal origin is a risk factor for several types of cancer, but the results for lymphomas are inconclusive. Therefore, we examined these associations among 411,097 participants of the European Prospective Investigation into Cancer and Nutrition. During a median follow-up of 8.5 years, 1,334 lymphomas (1,267 non-Hodgkin lymphoma (NHL) and 67 Hodgkin lymphomas) were identified. Consumption of red and processed meat, poultry, milk and dairy products was assessed by dietary questionnaires. Cox proportional hazard regression was used to evaluate the association of the consumption of these food groups with lymphoma risk. Overall, the consumption of foods of animal origin was not associated with an increased risk of NHLS or HL, but the associations with specific subgroups of NHL entities were noted. A high intake of processed meat was associated with an increased risk of B-cell chronic lymphocytic leukemia (BCLL) [relative risk (RR) per 50 g intake = 1.31, 95% confidence interval (CI) 1.06-1.63], but a decreased risk of follicular lymphomas (FL) (RR = 0.58; CI 0.38-0.89). A high intake of poultry was related to an increased risk of B-cell lymphomas (RR = 1.22; CI 1.05-1.42 per 10 g intake), FL (RR = 1.65; CI 1.18-2.32) and BCLL (RR = 1.54; CI 1.18-2.01) in the continuous models. In conclusion, no consistent associations between red and processed meat consumption and lymphoma risk were observed, but we found that the consumption of poultry was related to an increased risk of B-cell lymphomas. Chance is a plausible explanation of the observed associations, which need to be confirmed in further studies.
AB - The consumption of meat and other foods of animal origin is a risk factor for several types of cancer, but the results for lymphomas are inconclusive. Therefore, we examined these associations among 411,097 participants of the European Prospective Investigation into Cancer and Nutrition. During a median follow-up of 8.5 years, 1,334 lymphomas (1,267 non-Hodgkin lymphoma (NHL) and 67 Hodgkin lymphomas) were identified. Consumption of red and processed meat, poultry, milk and dairy products was assessed by dietary questionnaires. Cox proportional hazard regression was used to evaluate the association of the consumption of these food groups with lymphoma risk. Overall, the consumption of foods of animal origin was not associated with an increased risk of NHLS or HL, but the associations with specific subgroups of NHL entities were noted. A high intake of processed meat was associated with an increased risk of B-cell chronic lymphocytic leukemia (BCLL) [relative risk (RR) per 50 g intake = 1.31, 95% confidence interval (CI) 1.06-1.63], but a decreased risk of follicular lymphomas (FL) (RR = 0.58; CI 0.38-0.89). A high intake of poultry was related to an increased risk of B-cell lymphomas (RR = 1.22; CI 1.05-1.42 per 10 g intake), FL (RR = 1.65; CI 1.18-2.32) and BCLL (RR = 1.54; CI 1.18-2.01) in the continuous models. In conclusion, no consistent associations between red and processed meat consumption and lymphoma risk were observed, but we found that the consumption of poultry was related to an increased risk of B-cell lymphomas. Chance is a plausible explanation of the observed associations, which need to be confirmed in further studies.
KW - cohort study
KW - dairy consumption
KW - lymhomas
KW - meat consumption
UR - http://www.scopus.com/inward/record.url?scp=78649805294&partnerID=8YFLogxK
U2 - 10.1002/ijc.25387
DO - 10.1002/ijc.25387
M3 - Article
C2 - 20473877
AN - SCOPUS:78649805294
SN - 0020-7136
VL - 128
SP - 623
EP - 634
JO - International Journal of Cancer
JF - International Journal of Cancer
IS - 3
ER -
