Comparison of plasma lipoprotein composition and function in cerebral amyloid angiopathy and alzheimer’s disease

Anna Bonaterra-Pastra, Sofia Fernández-De-retana, Andrea Rivas-Urbina, Núria Puig, Sònia Benítez, Olalla Pancorbo, David Rodríguez-Luna, Francesc Pujadas, Maria Del Mar Freijo, Silvia Tur, Maite Martínez-Zabaleta, Pere Cardona Portela, Rocío Vera, Lucia Lebrato-Hernández, Juan F. Arenillas, Soledad Pérez-Sánchez, Joan Montaner, Jose Luis Sánchez-Quesada, Mar Hernández-Guillamon

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Resum

Cerebral amyloid angiopathy (CAA) refers to beta-amyloid (Aβ) deposition in brain vessels and is clinically the main cause of lobar intracerebral hemorrhage (ICH). Aβ can also accumulate in brain parenchyma forming neuritic plaques in Alzheimer’s disease (AD). Our study aimed to deter-mine whether the peripheral lipid profile and lipoprotein composition are associated with cerebral beta-amyloidosis pathology and may reflect biological differences in AD and CAA. For this purpose, lipid and apolipoproteins levels were analyzed in plasma from 51 ICH-CAA patients (collected during the chronic phase of the disease), 60 AD patients, and 60 control subjects. Lipoproteins (VLDL, LDL, and HDL) were isolated and their composition and pro/antioxidant ability were determined. We observed that alterations in the lipid profile and lipoprotein composition were remarkable in the ICH-CAA group compared to control subjects, whereas the AD group presented no specific alterations compared with controls. ICH-CAA patients presented an atheroprotective profile, which consisted of lower total and LDL cholesterol levels. Plasma from chronic ICH-CAA patients also showed a redistribution of ApoC-III from HDL to VLDL and a higher ApoE/ApoC-III ratio in HDL. Whether these alterations reflect a protective response or have a causative effect on the pathology requires further investigation.

Idioma originalAnglès
Número d’article72
Pàgines (de-a)1-14
Nombre de pàgines14
RevistaBiomedicines
Volum9
Número1
DOIs
Estat de la publicacióPublicada - 2021
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