CLIP-HSQMBC: Easy measurement of small proton-carbon coupling constants in organic molecules

Josep Saurí, Teodor Parella, Juan F. Espinosa*

*Autor corresponent d’aquest treball

Producció científica: Article en revista indexadaArticleAvaluat per experts

31 Cites (Scopus)

Resum

A user-friendly 2D NMR approach denoted as CLIP-HSQMBC is proposed for the very easy, direct and accurate measurement of long-range proton-carbon coupling constants in organic molecules and natural products. The J value can be extracted directly from the analysis of resolved in-phase 1H multiplets that show an additional splitting arising from the proton-carbon coupling. In cases of unresolved peaks, a simple fitting analysis using the internal satellite lines as a reference is performed. Addition of a spin-lock period results in a CLIP-HSQMBC-TOCSY experiment that is suitable for the measurement of very small coupling values or to observe correlations from overlapped resonances.

Idioma originalAnglès
Pàgines (de-a)4473-4478
Nombre de pàgines6
RevistaOrganic and Biomolecular Chemistry
Volum11
Número27
DOIs
Estat de la publicacióPublicada - 21 de jul. 2013
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