Resum
A user-friendly 2D NMR approach denoted as CLIP-HSQMBC is proposed for the very easy, direct and accurate measurement of long-range proton-carbon coupling constants in organic molecules and natural products. The J value can be extracted directly from the analysis of resolved in-phase 1H multiplets that show an additional splitting arising from the proton-carbon coupling. In cases of unresolved peaks, a simple fitting analysis using the internal satellite lines as a reference is performed. Addition of a spin-lock period results in a CLIP-HSQMBC-TOCSY experiment that is suitable for the measurement of very small coupling values or to observe correlations from overlapped resonances.
Idioma original | Anglès |
---|---|
Pàgines (de-a) | 4473-4478 |
Nombre de pàgines | 6 |
Revista | Organic and Biomolecular Chemistry |
Volum | 11 |
Número | 27 |
DOIs | |
Estat de la publicació | Publicada - 21 de jul. 2013 |
Publicat externament | Sí |