TY - JOUR
T1 - Clinical impact of comorbid major depression in subjects with posttraumatic stress disorder
T2 - A review of the literature
AU - Frías, Álvaro
AU - Martínez, Bárbara
AU - Palma, Cárol
AU - Farriols, Núria
N1 - Publisher Copyright:
© 2016 The Editors of Nordic Psychology.
PY - 2016/10/1
Y1 - 2016/10/1
N2 - Nearly half of those with posttraumatic stress disorder (PTSD) have co-occurring major depressive disorder. Some etiopathogenic theories and treatments have been postulated for this comorbidity. However, there are no systematic reviews aimed at addressing the clinical impact of comorbid major depression in the PTSD profile. A comprehensive database search was performed from 1985 to February 2015. Overall, 94 studies fulfilled the inclusion criteria. The main evidence is described concerning several clinical criteria: PTSD symptoms and other psychopathology (suicide ideation/attempts or/and alcohol misuse), disability (quality of life and/or medical conditions), natural course, and treatment-related features (treatment seeking, response to treatment, and/or treatment compliance/preference). Overall, comorbid major depression tends to exert a deleterious role on the PTSD profile. This negative effect is mainly found regarding the symptomatology, disability, and natural course of PTSD. Methodological divergences are discussed with respect to inconsistent findings.
AB - Nearly half of those with posttraumatic stress disorder (PTSD) have co-occurring major depressive disorder. Some etiopathogenic theories and treatments have been postulated for this comorbidity. However, there are no systematic reviews aimed at addressing the clinical impact of comorbid major depression in the PTSD profile. A comprehensive database search was performed from 1985 to February 2015. Overall, 94 studies fulfilled the inclusion criteria. The main evidence is described concerning several clinical criteria: PTSD symptoms and other psychopathology (suicide ideation/attempts or/and alcohol misuse), disability (quality of life and/or medical conditions), natural course, and treatment-related features (treatment seeking, response to treatment, and/or treatment compliance/preference). Overall, comorbid major depression tends to exert a deleterious role on the PTSD profile. This negative effect is mainly found regarding the symptomatology, disability, and natural course of PTSD. Methodological divergences are discussed with respect to inconsistent findings.
KW - clinical impact
KW - comorbidity
KW - major depression
KW - posttraumatic stress disorder
KW - theoretical review
UR - https://www.scopus.com/pages/publications/84962546278
UR - http://webofscience.com/wos/woscc/full-record/WOS:000388744500005
U2 - 10.1080/19012276.2016.1162106
DO - 10.1080/19012276.2016.1162106
M3 - Review
AN - SCOPUS:84962546278
SN - 1901-2276
VL - 68
SP - 257
EP - 271
JO - Nordic Psychology
JF - Nordic Psychology
IS - 4
ER -
