Clinical assessment of peripheral muscle function in patients with chronic obstructive pulmonary disease

Jordi Vilaro, Roberto Rabinovich, Jose Manuel Gonzalez-deSuso, Thierry Troosters, D. A. Rodríguez, Joan Albert Barberà, Josep Roca

Producció científica: Article en revista indexadaArticleAvaluat per experts

38 Cites (Scopus)


Objective: Correlation of muscle function, muscle mass and endurance, and exercise tolerance in chronic obstructive pulmonary disease (COPD). Design: Sixteen COPD patients (forced expiratory volume during the first second 38 ± 15% predicted) and 6 controls underwent magnetic resonance imaging of the thigh, muscle strength and endurance, and exercise tolerance assessments. Results: Thigh mass distribution was bimodal (cutoff 19.0 kg m-2). Six COPD patients (16 ± 2.5 kg m-2) (P < 0.05) presented reduced thigh mass (COPDLQ), whereas 10 patients with normal quadriceps mass (COPDNQ) and all controls had identical mass distribution (22 ± 2.4 kg m-2). COPDLQ patients had lower muscle function and lower exercise tolerance than both COPDNQ and controls (P < 0.05 each), but muscle strength corrected by mass was similar between COPD patients (COPDLQ 0.59 ±0.12 and COPD NQ 0.55 ± 0.10 Nm kg-1 m-2) and controls (0.62 ± 0.04 Nm Kg-1 m-2). In contrast, endurance to muscle mass ratio was lower in COPD (COPDLQ and COPDNQ 0.91 ± 0.15 and 0.89 ± 0.15 J kg-1 m-2) than in controls (1.07 ± 0.11 J kg-1 m-2) (P < 0.05). Half-time phosphocreatine recovery (COPDLQ 66 ± 14 and COPDNQ 55 ± 9 secs, not significant) was also slower than in controls (43 ± 10 secs) (P < 0.01). Conclusions: Impaired muscle strength was explained by reduced muscle mass, but it did not account for abnormal muscle endurance. The latter seems associated to impaired O2 transport/O2 utilization, resulting in altered muscle bioenergetics. American Journal of Physical Medicine & Rehabilitation

Idioma originalAnglès
Pàgines (de-a)39-46
Nombre de pàgines8
RevistaAmerican Journal of Physical Medicine and Rehabilitation
Estat de la publicacióPublicada - de gen. 2009


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