Resum
The challenging structural motif of dictyospiromide (1), a spirosuccinimide alkaloid with antioxidant properties that are associated with activation of the Nrf2/ARE signaling pathway, was assigned using contemporary NMR experiments complemented with anisotropic NMR, chiroptical, and computational methodologies. Anisotropic NMR parameters provided critical orthogonal verification of the configuration of the difficult to assign spiro carbon and the other stereogenic centers in 1.
Idioma original | Anglès |
---|---|
Pàgines (de-a) | 7577-7581 |
Nombre de pàgines | 5 |
Revista | Organic Letters |
Volum | 21 |
Número | 18 |
DOIs | |
Estat de la publicació | Publicada - 20 de set. 2019 |
Publicat externament | Sí |