Characterization by Empirical and Computational Methods of Dictyospiromide, an Intriguing Antioxidant Alkaloid from the Marine Alga Dictyota coriacea

Pengcheng Yan, Ge Li, Chaojie Wang, Jianzhang Wu, Zhongmin Sun, Gary E. Martin, Xiao Wang, Mikhail Reibarkh, Josep Sauri, Kirk R. Gustafson

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Resum

The challenging structural motif of dictyospiromide (1), a spirosuccinimide alkaloid with antioxidant properties that are associated with activation of the Nrf2/ARE signaling pathway, was assigned using contemporary NMR experiments complemented with anisotropic NMR, chiroptical, and computational methodologies. Anisotropic NMR parameters provided critical orthogonal verification of the configuration of the difficult to assign spiro carbon and the other stereogenic centers in 1.
Idioma originalAnglès
Pàgines (de-a)7577-7581
Nombre de pàgines5
RevistaOrganic Letters
Volum21
Número18
DOIs
Estat de la publicacióPublicada - 20 de set. 2019
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