Characterisation of three polymorphisms of the tryptophan hydroxylase 2 gene in a sample of Colombian population with major depressive disorder

Adriana Martínez-Idárraga, Irene Riveros-Barrera, Ricardo Sánchez, Luis Eduardo Jaramillo, José Manuel Calvo-Gómez, Juan José Yunis-Londoño

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Objective Identify whether rs11179000, rs136494 and rs4570625 polymorphisms of the tryptophan hydroxylase 2 gene, are associated with a major depressive disorder in a sample of the Colombian population. Methods Case-control study was conducted in which a comparison was made between subjects diagnosed with major depressive disorder at some point in adulthood or active symptoms at the time of evaluation, and subjects with no psychiatric disease. Subjects were studied in the Department of Psychiatry, Faculty of Medicine and the Institute of Genetics at the National University of Colombia. Polymorphisms were genotyped using Taqman probes in real time PCR. As well as studying the association between major depressive disorder and these (single nucleotide polymorphisms (SNPs), the association with other factors previously associated with depression were also analysed. Results No statistically significant association between genotypic and allelic frequencies of each polymorphism and major depressive disorder was found. Association between sex and complication during pregnancy / childbirth and major depressive disorder was observed. Association between sex and complication during pregnancy / childbirth and major depressive disorder was observed. Conclusions There was no association between any polymorphism and major depressive disorder.

Títol traduït de la contribucióCaracterización de tres polimorfismos del gen de la triptófano hidroxilasa 2 en una muestra de población colombiana con trastorno depresivo mayor
Idioma originalAnglès
Pàgines (de-a)22-30
Nombre de pàgines9
RevistaRevista Colombiana de Psiquiatria
Volum46
Número1
DOIs
Estat de la publicacióPublicada - 1 de gen. 2017
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