TY - JOUR
T1 - Characterisation of three polymorphisms of the tryptophan hydroxylase 2 gene in a sample of Colombian population with major depressive disorder
AU - Martínez-Idárraga, Adriana
AU - Riveros-Barrera, Irene
AU - Sánchez, Ricardo
AU - Jaramillo, Luis Eduardo
AU - Calvo-Gómez, José Manuel
AU - Yunis-Londoño, Juan José
N1 - Publisher Copyright:
© 2016 Asociación Colombiana de Psiquiatría
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Objective Identify whether rs11179000, rs136494 and rs4570625 polymorphisms of the tryptophan hydroxylase 2 gene, are associated with a major depressive disorder in a sample of the Colombian population. Methods Case-control study was conducted in which a comparison was made between subjects diagnosed with major depressive disorder at some point in adulthood or active symptoms at the time of evaluation, and subjects with no psychiatric disease. Subjects were studied in the Department of Psychiatry, Faculty of Medicine and the Institute of Genetics at the National University of Colombia. Polymorphisms were genotyped using Taqman probes in real time PCR. As well as studying the association between major depressive disorder and these (single nucleotide polymorphisms (SNPs), the association with other factors previously associated with depression were also analysed. Results No statistically significant association between genotypic and allelic frequencies of each polymorphism and major depressive disorder was found. Association between sex and complication during pregnancy / childbirth and major depressive disorder was observed. Association between sex and complication during pregnancy / childbirth and major depressive disorder was observed. Conclusions There was no association between any polymorphism and major depressive disorder.
AB - Objective Identify whether rs11179000, rs136494 and rs4570625 polymorphisms of the tryptophan hydroxylase 2 gene, are associated with a major depressive disorder in a sample of the Colombian population. Methods Case-control study was conducted in which a comparison was made between subjects diagnosed with major depressive disorder at some point in adulthood or active symptoms at the time of evaluation, and subjects with no psychiatric disease. Subjects were studied in the Department of Psychiatry, Faculty of Medicine and the Institute of Genetics at the National University of Colombia. Polymorphisms were genotyped using Taqman probes in real time PCR. As well as studying the association between major depressive disorder and these (single nucleotide polymorphisms (SNPs), the association with other factors previously associated with depression were also analysed. Results No statistically significant association between genotypic and allelic frequencies of each polymorphism and major depressive disorder was found. Association between sex and complication during pregnancy / childbirth and major depressive disorder was observed. Association between sex and complication during pregnancy / childbirth and major depressive disorder was observed. Conclusions There was no association between any polymorphism and major depressive disorder.
KW - Genetic variation
KW - Genotype
KW - Major depressive disorder
KW - Single nucleotide polymorphism
KW - Tryptophan hydroxylase 2
UR - http://www.scopus.com/inward/record.url?scp=85006189332&partnerID=8YFLogxK
U2 - 10.1016/j.rcp.2016.03.007
DO - 10.1016/j.rcp.2016.03.007
M3 - Article
C2 - 28193370
AN - SCOPUS:85006189332
SN - 0034-7450
VL - 46
SP - 22
EP - 30
JO - Revista Colombiana de Psiquiatria
JF - Revista Colombiana de Psiquiatria
IS - 1
ER -