Caracterización de los descendientes de padres con trastorno bipolar: Una revisión de la literatura

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Offspring of parents with bipolar disorder (O-BP) is a high-risk cohort for mental illness in general and bipolar disorder (BD) specifically. This review aims to delineate the main clinical features of O-BP, including the psychopathology, interpersonal functioning, temperamental and personality features, neurocognitive deficits and neurobiological dysfunctions. Evidence indicates that several internalizing and externalizing symptoms/disorders are more prevalent in O-BP than in offspring of healthy control parents (O-HC). Furthermore, O-BP exhibits poorer interpersonal functioning than O-HC. Moreover, O-BP also endorses higher activity level, emotionality and behavioral disinhibition compared to O-HC. Besides, O-BP displays greater deficits on memory, cognitive flexibility and social cognition compared to O-HC. Finally, O-BP exhibits dysfunctional modulation in cortico- subcortical areas, more white matter abnormalities and higher cortisol basal levels compared to O-HC. Overall, these findings are discussed regarding the natural course and potential risk factors or endophenotypes for major mood disorders in general and BD specifically.

Títol traduït de la contribucióCharacterizing offspring of bipolar parents: A review of the literature
Idioma originalCastellà
Pàgines (de-a)221-234
Nombre de pàgines14
RevistaActas Espanolas de Psiquiatria
Estat de la publicacióPublicada - 1 de nov. 2015


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