C20-nor-Abietane and Three Abietane Diterpenoids from Plectranthus mutabilis Leaves as P-Glycoprotein Modulators

Epole N. Ntungwe; Sofija Jovanovic Stojanov; Noelia M. Duarte; Nuno R. Candeias; Ana M. Diaz-Lanza; Mate Vagvolgyi; Attila Hunyadi; Milica Pesic; Patricia Rijo

doi:10.1021/acsmedchemlett.1c00711

C20-nor-Abietane and Three Abietane Diterpenoids from Plectranthus mutabilis Leaves as P-Glycoprotein Modulators

Epole N. Ntungwe
, Sofija Jovanovic Stojanov
, Noelia M. Duarte
, Nuno R. Candeias
, Ana M. Diaz-Lanza
, Mate Vagvolgyi
, Attila Hunyadi
, Milica Pesic
, Patricia Rijo

Producció científica: Article en revista indexada › Article › Avaluat per experts

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In this study, a bioguided fractionation ofPlectranthus mutabilisextract was performed by chromatographicmethods. It yielded one newnor-abietane diterpene, mutabilol (1),and three known abietanes, coleon-U-quinone (2), 8 alpha,9 alpha-epoxycoleon-U-quinone (3), and coleon U (4). The abietanediterpenoid5was also tentatively identified using HPLC-MS/MS.Moreover, the extract profile and quantification of each isolatedcompound were determined by HPLC-DAD. Compound4was themajor compound in the extract. Compounds2-4were found to beselective toward cancer cell lines and were able to inhibit P-glycoprotein (P-gp) activity in NCI-H460/R cells at longerexposure of 72 h and consequently revert doxorubicin (DOX)resistance in subsequent combined treatment. None of thecompounds influenced the P-gp expression in NCI-H460/R cells, while the extract significantly increased it

Idioma original	Anglès
Pàgines (de-a)	674-680
Nombre de pàgines	7
Revista	Acs Medicinal Chemistry Letters
Volum	13
Número	4
DOIs	https://doi.org/10.1021/acsmedchemlett.1c00711
Estat de la publicació	Publicada - 14 d’abr. 2022
Publicat externament	Sí

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title = "C20-nor-Abietane and Three Abietane Diterpenoids from Plectranthus mutabilis Leaves as P-Glycoprotein Modulators",

abstract = "In this study, a bioguided fractionation ofPlectranthus mutabilisextract was performed by chromatographicmethods. It yielded one newnor-abietane diterpene, mutabilol (1),and three known abietanes, coleon-U-quinone (2), 8 alpha,9 alpha-epoxycoleon-U-quinone (3), and coleon U (4). The abietanediterpenoid5was also tentatively identified using HPLC-MS/MS.Moreover, the extract profile and quantification of each isolatedcompound were determined by HPLC-DAD. Compound4was themajor compound in the extract. Compounds2-4were found to beselective toward cancer cell lines and were able to inhibit P-glycoprotein (P-gp) activity in NCI-H460/R cells at longerexposure of 72 h and consequently revert doxorubicin (DOX)resistance in subsequent combined treatment. None of thecompounds influenced the P-gp expression in NCI-H460/R cells, while the extract significantly increased it",

keywords = "P-glycoprotei, Plectranthus mutabilis, Abietane diterpenoids, Anticancer effect, Multidrug resistance",

author = "Ntungwe, \{Epole N.\} and Stojanov, \{Sofija Jovanovic\} and Duarte, \{Noelia M.\} and Candeias, \{Nuno R.\} and Diaz-Lanza, \{Ana M.\} and Mate Vagvolgyi and Attila Hunyadi and Milica Pesic and Patricia Rijo",

year = "2022",

month = apr,

day = "14",

doi = "10.1021/acsmedchemlett.1c00711",

language = "English",

volume = "13",

pages = "674--680",

journal = "Acs Medicinal Chemistry Letters",

issn = "1948-5875",

publisher = "Amer Chemical Soc",

number = "4",

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T1 - C20-nor-Abietane and Three Abietane Diterpenoids from Plectranthus mutabilis Leaves as P-Glycoprotein Modulators

AU - Ntungwe, Epole N.

AU - Stojanov, Sofija Jovanovic

AU - Duarte, Noelia M.

AU - Candeias, Nuno R.

AU - Diaz-Lanza, Ana M.

AU - Vagvolgyi, Mate

AU - Hunyadi, Attila

AU - Pesic, Milica

AU - Rijo, Patricia

PY - 2022/4/14

Y1 - 2022/4/14

N2 - In this study, a bioguided fractionation ofPlectranthus mutabilisextract was performed by chromatographicmethods. It yielded one newnor-abietane diterpene, mutabilol (1),and three known abietanes, coleon-U-quinone (2), 8 alpha,9 alpha-epoxycoleon-U-quinone (3), and coleon U (4). The abietanediterpenoid5was also tentatively identified using HPLC-MS/MS.Moreover, the extract profile and quantification of each isolatedcompound were determined by HPLC-DAD. Compound4was themajor compound in the extract. Compounds2-4were found to beselective toward cancer cell lines and were able to inhibit P-glycoprotein (P-gp) activity in NCI-H460/R cells at longerexposure of 72 h and consequently revert doxorubicin (DOX)resistance in subsequent combined treatment. None of thecompounds influenced the P-gp expression in NCI-H460/R cells, while the extract significantly increased it

AB - In this study, a bioguided fractionation ofPlectranthus mutabilisextract was performed by chromatographicmethods. It yielded one newnor-abietane diterpene, mutabilol (1),and three known abietanes, coleon-U-quinone (2), 8 alpha,9 alpha-epoxycoleon-U-quinone (3), and coleon U (4). The abietanediterpenoid5was also tentatively identified using HPLC-MS/MS.Moreover, the extract profile and quantification of each isolatedcompound were determined by HPLC-DAD. Compound4was themajor compound in the extract. Compounds2-4were found to beselective toward cancer cell lines and were able to inhibit P-glycoprotein (P-gp) activity in NCI-H460/R cells at longerexposure of 72 h and consequently revert doxorubicin (DOX)resistance in subsequent combined treatment. None of thecompounds influenced the P-gp expression in NCI-H460/R cells, while the extract significantly increased it

KW - P-glycoprotei

KW - Plectranthus mutabilis

KW - Abietane diterpenoids

KW - Anticancer effect

KW - Multidrug resistance

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JO - Acs Medicinal Chemistry Letters

JF - Acs Medicinal Chemistry Letters

IS - 4

ER -

C20-nor-Abietane and Three Abietane Diterpenoids from Plectranthus mutabilis Leaves as P-Glycoprotein Modulators

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