C-Cbl, a ubiquitin E3 ligase that targets active β-Catenin: A novel layer of Wnt signaling regulation

Vipul Chitalia; Sowmya Shivanna; Jordi Martorell; Rosana Meyer; Elazer Edelman; Nader Rahimi

doi:10.1074/jbc.M113.473801

C-Cbl, a ubiquitin E3 ligase that targets active β-Catenin: A novel layer of Wnt signaling regulation

Vipul Chitalia, Sowmya Shivanna, Jordi Martorell, Rosana Meyer, Elazer Edelman, Nader Rahimi

Producció científica: Article en revista indexada › Article › Avaluat per experts

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Background: Several E3 ligases regulate cytosolicβ-catenin during Wnt-off phase. The fate of critical form activeβ-catenin in Wnt-on phase remains poorly defined. Results: Casitas B-lineage lymphoma (c-Cbl) ubiquitinates cytosolic β-catenin and translocates to the nucleus with Wnt induction to also ubiquitinate active nuclear β-catenin. Conclusion: c-Cbl is a unique E3 ligase targeting active nuclear β-catenin. Significance: This study uncovers a novel layer of Wnt regulation.

Idioma original	Anglès
Pàgines (de-a)	23505-23517
Nombre de pàgines	13
Revista	Journal of Biological Chemistry
Volum	288
Número	32
DOIs	https://doi.org/10.1074/jbc.M113.473801
Estat de la publicació	Publicada - 9 d’ag. 2013
Publicat externament	Sí

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title = "C-Cbl, a ubiquitin E3 ligase that targets active β-Catenin: A novel layer of Wnt signaling regulation",

abstract = "Background: Several E3 ligases regulate cytosolicβ-catenin during Wnt-off phase. The fate of critical form activeβ-catenin in Wnt-on phase remains poorly defined. Results: Casitas B-lineage lymphoma (c-Cbl) ubiquitinates cytosolic β-catenin and translocates to the nucleus with Wnt induction to also ubiquitinate active nuclear β-catenin. Conclusion: c-Cbl is a unique E3 ligase targeting active nuclear β-catenin. Significance: This study uncovers a novel layer of Wnt regulation.",

author = "Vipul Chitalia and Sowmya Shivanna and Jordi Martorell and Rosana Meyer and Elazer Edelman and Nader Rahimi",

year = "2013",

month = aug,

day = "9",

doi = "10.1074/jbc.M113.473801",

language = "English",

volume = "288",

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journal = "Journal of Biological Chemistry",

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T1 - C-Cbl, a ubiquitin E3 ligase that targets active β-Catenin

T2 - A novel layer of Wnt signaling regulation

AU - Chitalia, Vipul

AU - Shivanna, Sowmya

AU - Martorell, Jordi

AU - Meyer, Rosana

AU - Edelman, Elazer

AU - Rahimi, Nader

PY - 2013/8/9

Y1 - 2013/8/9

N2 - Background: Several E3 ligases regulate cytosolicβ-catenin during Wnt-off phase. The fate of critical form activeβ-catenin in Wnt-on phase remains poorly defined. Results: Casitas B-lineage lymphoma (c-Cbl) ubiquitinates cytosolic β-catenin and translocates to the nucleus with Wnt induction to also ubiquitinate active nuclear β-catenin. Conclusion: c-Cbl is a unique E3 ligase targeting active nuclear β-catenin. Significance: This study uncovers a novel layer of Wnt regulation.

AB - Background: Several E3 ligases regulate cytosolicβ-catenin during Wnt-off phase. The fate of critical form activeβ-catenin in Wnt-on phase remains poorly defined. Results: Casitas B-lineage lymphoma (c-Cbl) ubiquitinates cytosolic β-catenin and translocates to the nucleus with Wnt induction to also ubiquitinate active nuclear β-catenin. Conclusion: c-Cbl is a unique E3 ligase targeting active nuclear β-catenin. Significance: This study uncovers a novel layer of Wnt regulation.

UR - http://www.scopus.com/inward/record.url?scp=84881425239&partnerID=8YFLogxK

U2 - 10.1074/jbc.M113.473801

DO - 10.1074/jbc.M113.473801

M3 - Article

C2 - 23744067

AN - SCOPUS:84881425239

SN - 0021-9258

VL - 288

SP - 23505

EP - 23517

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 32

ER -

C-Cbl, a ubiquitin E3 ligase that targets active β-Catenin: A novel layer of Wnt signaling regulation

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