TY - JOUR
T1 - Blood-brain barrier shuttle peptides
T2 - An emerging paradigm for brain delivery
AU - Oller-Salvia, Benjamí
AU - Sánchez-Navarro, MacArena
AU - Giralt, Ernest
AU - Teixidó, Meritxell
N1 - Publisher Copyright:
© 2016 The Royal Society of Chemistry.
PY - 2016/9/7
Y1 - 2016/9/7
N2 - Brain delivery is one of the major challenges in drug development because of the high number of patients suffering from neural diseases and the low efficiency of the treatments available. Although the blood-brain barrier (BBB) prevents most drugs from reaching their targets, molecular vectors-known as BBB shuttles-offer great promise to safely overcome this formidable obstacle. In recent years, peptide shuttles have received growing attention because of their lower cost, reduced immunogenicity, and higher chemical versatility than traditional Trojan horse antibodies and other proteins.
AB - Brain delivery is one of the major challenges in drug development because of the high number of patients suffering from neural diseases and the low efficiency of the treatments available. Although the blood-brain barrier (BBB) prevents most drugs from reaching their targets, molecular vectors-known as BBB shuttles-offer great promise to safely overcome this formidable obstacle. In recent years, peptide shuttles have received growing attention because of their lower cost, reduced immunogenicity, and higher chemical versatility than traditional Trojan horse antibodies and other proteins.
UR - http://www.scopus.com/inward/record.url?scp=84982218324&partnerID=8YFLogxK
U2 - 10.1039/c6cs00076b
DO - 10.1039/c6cs00076b
M3 - Review
C2 - 27188322
AN - SCOPUS:84982218324
SN - 0306-0012
VL - 45
SP - 4690
EP - 4707
JO - Chemical Society Reviews
JF - Chemical Society Reviews
IS - 17
ER -