TY - JOUR
T1 - Biomarkers associated with sedentary behaviour in older adults
T2 - A systematic review
AU - Wirth, Katharina
AU - Klenk, Jochen
AU - Brefka, Simone
AU - Dallmeier, Dhayana
AU - Faehling, Kathrin
AU - Roqué i Figuls, Marta
AU - Tully, Mark A.
AU - Giné-Garriga, Maria
AU - Caserotti, Paolo
AU - Salvà, Antoni
AU - Rothenbacher, Dietrich
AU - Denkinger, Michael
AU - Stubbs, Brendon
N1 - Publisher Copyright:
© 2016 The Authors
PY - 2017/5/1
Y1 - 2017/5/1
N2 - Objective Pathomechanisms of sedentary behaviour (SB) are unclear. We conducted a systematic review to investigate the associations between SB and various biomarkers in older adults. Methods Electronic databases were searched (MEDLINE, EMBASE, CINAHL, AMED) up to July 2015 to identify studies with objective or subjective measures of SB, sample size ≥50, mean age ≥60 years and accelerometer wear time ≥3 days. Methodological quality was appraised with the CASP tool. The protocol was pre-specified (PROSPERO CRD42015023731). Results 12701 abstracts were retrieved, 275 full text articles further explored, from which 249 were excluded. In the final sample (26 articles) a total of 63 biomarkers were detected. Most investigated markers were: body mass index (BMI, n = 15), waist circumference (WC, n = 15), blood pressure (n = 11), triglycerides (n = 12) and high density lipoprotein (HDL, n = 15). Some inflammation markers were identified such as interleukin-6, C-reactive protein or tumor necrosis factor alpha. There was a lack of renal, muscle or bone biomarkers. Randomized controlled trials found a positive correlation for SB with BMI, neck circumference, fat mass, HbA1C, cholesterol and insulin levels, cohort studies additionally for WC, leptin, C-peptide, ApoA1 and Low density lipoprotein and a negative correlation for HDL. Conclusion Most studied biomarkers associated with SB were of cardiovascular or metabolic origin. There is a suggestion of a negative impact of SB on biomarkers but still a paucity of high quality investigations exist. Longitudinal studies with objectively measured SB are needed to further elucidate the pathophysiological pathways and possible associations of unexplored biomarkers.
AB - Objective Pathomechanisms of sedentary behaviour (SB) are unclear. We conducted a systematic review to investigate the associations between SB and various biomarkers in older adults. Methods Electronic databases were searched (MEDLINE, EMBASE, CINAHL, AMED) up to July 2015 to identify studies with objective or subjective measures of SB, sample size ≥50, mean age ≥60 years and accelerometer wear time ≥3 days. Methodological quality was appraised with the CASP tool. The protocol was pre-specified (PROSPERO CRD42015023731). Results 12701 abstracts were retrieved, 275 full text articles further explored, from which 249 were excluded. In the final sample (26 articles) a total of 63 biomarkers were detected. Most investigated markers were: body mass index (BMI, n = 15), waist circumference (WC, n = 15), blood pressure (n = 11), triglycerides (n = 12) and high density lipoprotein (HDL, n = 15). Some inflammation markers were identified such as interleukin-6, C-reactive protein or tumor necrosis factor alpha. There was a lack of renal, muscle or bone biomarkers. Randomized controlled trials found a positive correlation for SB with BMI, neck circumference, fat mass, HbA1C, cholesterol and insulin levels, cohort studies additionally for WC, leptin, C-peptide, ApoA1 and Low density lipoprotein and a negative correlation for HDL. Conclusion Most studied biomarkers associated with SB were of cardiovascular or metabolic origin. There is a suggestion of a negative impact of SB on biomarkers but still a paucity of high quality investigations exist. Longitudinal studies with objectively measured SB are needed to further elucidate the pathophysiological pathways and possible associations of unexplored biomarkers.
KW - Biomarker
KW - Older adults
KW - Sedentary behaviour
UR - http://www.scopus.com/inward/record.url?scp=85012285871&partnerID=8YFLogxK
U2 - 10.1016/j.arr.2016.12.002
DO - 10.1016/j.arr.2016.12.002
M3 - Review
C2 - 28025174
AN - SCOPUS:85012285871
SN - 1568-1637
VL - 35
SP - 87
EP - 111
JO - Ageing Research Reviews
JF - Ageing Research Reviews
ER -