TY - JOUR
T1 - Bioengineering 3D environments for cancer models
AU - Alemany-Ribes, Mireia
AU - Semino, Carlos E.
N1 - Funding Information:
The authors want to thank Jessica Reik for her help in writing this manuscript and Mercedes Balcells-Camps for her critical revision and helpful comments. This research was supported by the IQS-School of Engineering , Bioengineering Department Budget to C.E.S (Grant number 982 ). M.A.-R. Thanks to the Comissionat per a Universitats i Recerca del Departament d'Innovació, Universitats i Empresa de la Generalitat de Catalunya i del Fons Social Europeu for a predoctoral fellowship.
Publisher Copyright:
© 2014 Elsevier B.V.
PY - 2014/12/15
Y1 - 2014/12/15
N2 - Tumor development is a dynamic process where cancer cells differentiate, proliferate and migrate interacting among each other and with the surrounding matrix in a three-dimensional (3D) context. Interestingly, the process follows patterns similar to those involved in early tissue formation by accessing specific genetic programs to grow and disseminate. Thus, the complex biological mechanisms driving tumor progression cannot easily be recreated in the laboratory. Yet, essential tumor stages, including epithelial-mesenchymal transition (EMT), tumor-induced angiogenesis and metastasis, urgently need more realistic models in order to unravel the underlying molecular and cellular mechanisms that govern them. The latest implementation of successful 3D models is having a positive impact on the fight against cancer by obtaining more predictive systems for pre-clinical research, therapeutic drug screening, and early cancer diagnosis. In this review we explore the latest advances and challenges in tumor tissue engineering, by accessing knowledge and tools from cancer biology, material science and bioengineering.
AB - Tumor development is a dynamic process where cancer cells differentiate, proliferate and migrate interacting among each other and with the surrounding matrix in a three-dimensional (3D) context. Interestingly, the process follows patterns similar to those involved in early tissue formation by accessing specific genetic programs to grow and disseminate. Thus, the complex biological mechanisms driving tumor progression cannot easily be recreated in the laboratory. Yet, essential tumor stages, including epithelial-mesenchymal transition (EMT), tumor-induced angiogenesis and metastasis, urgently need more realistic models in order to unravel the underlying molecular and cellular mechanisms that govern them. The latest implementation of successful 3D models is having a positive impact on the fight against cancer by obtaining more predictive systems for pre-clinical research, therapeutic drug screening, and early cancer diagnosis. In this review we explore the latest advances and challenges in tumor tissue engineering, by accessing knowledge and tools from cancer biology, material science and bioengineering.
KW - Biomaterials
KW - Cancer models
KW - Drug resistance
KW - Drug screening
KW - Nanotechnology
KW - Three-dimensional culture
KW - Tumor tissue engineering
KW - Tumorigenesis
UR - http://www.scopus.com/inward/record.url?scp=84919691161&partnerID=8YFLogxK
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=pure_univeritat_ramon_llull&SrcAuth=WosAPI&KeyUT=WOS:000347604400005&DestLinkType=FullRecord&DestApp=WOS_CPL
U2 - 10.1016/j.addr.2014.06.004
DO - 10.1016/j.addr.2014.06.004
M3 - Review
C2 - 24996134
AN - SCOPUS:84919691161
SN - 0169-409X
VL - 79
SP - 40
EP - 49
JO - Advanced Drug Delivery Reviews
JF - Advanced Drug Delivery Reviews
ER -
