Band-Selective 2D HSQMBC: A Universal Technique for Detection and Measurement of <SUP>35,37</SUP>Cl Isotope Effects for <SUP>13</SUP>C Nuclei

A novel technique that allows efficient measurement of the Cl-35,Cl-37 isotope pattern for any C-13 resonance has been developed. The band-selective CLIP-HSQMBC experiment is reliable and universally applicable for the indirect measurement of the Cl-35,Cl-37 isotope shift of C-13 resonances. The experiment provides advantages over conventional 1D C-13 NMR. and the recently developed bs-HSQC experiments. The utility and performance of the bs-CLIP-HSQMBC experiment is demonstrated for polyhalogenated synthons in a synthetic route and for a polyhalogenated marine natural product.