Band-Selective 2D HSQMBC: A Universal Technique for Detection and Measurement of 35,37Cl Isotope Effects for 13C Nuclei

Josep Sauri; Mikhail Reibarkh; Ting Zhang; Ryan D. Cohen; Xiao Wang; Tadeusz F. Molinski; Gary E. Martin; R. Thomas Williamson

doi:10.1021/acs.orglett.6b02158

Band-Selective 2D HSQMBC: A Universal Technique for Detection and Measurement of 35,37Cl Isotope Effects for 13C Nuclei

Josep Sauri, Mikhail Reibarkh, Ting Zhang, Ryan D. Cohen, Xiao Wang, Tadeusz F. Molinski, Gary E. Martin, R. Thomas Williamson

Producció científica: Article en revista indexada › Article › Avaluat per experts

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A novel technique that allows efficient measurement of the Cl-35,Cl-37 isotope pattern for any C-13 resonance has been developed. The band-selective CLIP-HSQMBC experiment is reliable and universally applicable for the indirect measurement of the Cl-35,Cl-37 isotope shift of C-13 resonances. The experiment provides advantages over conventional 1D C-13 NMR. and the recently developed bs-HSQC experiments. The utility and performance of the bs-CLIP-HSQMBC experiment is demonstrated for polyhalogenated synthons in a synthetic route and for a polyhalogenated marine natural product.

Idioma original	Anglès
Pàgines (de-a)	4786-4789
Nombre de pàgines	4
Revista	Organic Letters
Volum	18
Número	19
DOIs	https://doi.org/10.1021/acs.orglett.6b02158
Estat de la publicació	Publicada - 7 d’oct. 2016
Publicat externament	Sí

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title = "Band-Selective 2D HSQMBC: A Universal Technique for Detection and Measurement of 35,37Cl Isotope Effects for 13C Nuclei",

abstract = "A novel technique that allows efficient measurement of the Cl-35,Cl-37 isotope pattern for any C-13 resonance has been developed. The band-selective CLIP-HSQMBC experiment is reliable and universally applicable for the indirect measurement of the Cl-35,Cl-37 isotope shift of C-13 resonances. The experiment provides advantages over conventional 1D C-13 NMR. and the recently developed bs-HSQC experiments. The utility and performance of the bs-CLIP-HSQMBC experiment is demonstrated for polyhalogenated synthons in a synthetic route and for a polyhalogenated marine natural product.",

keywords = "Quantum coherence, Natural-products, Chemical-shifts, Assignment",

author = "Josep Sauri and Mikhail Reibarkh and Ting Zhang and Cohen, {Ryan D.} and Xiao Wang and Molinski, {Tadeusz F.} and Martin, {Gary E.} and Williamson, {R. Thomas}",

year = "2016",

month = oct,

day = "7",

doi = "10.1021/acs.orglett.6b02158",

language = "English",

volume = "18",

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journal = "Organic Letters",

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publisher = "American Chemical Society",

number = "19",

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T1 - Band-Selective 2D HSQMBC

T2 - A Universal Technique for Detection and Measurement of 35,37Cl Isotope Effects for 13C Nuclei

AU - Sauri, Josep

AU - Reibarkh, Mikhail

AU - Zhang, Ting

AU - Cohen, Ryan D.

AU - Wang, Xiao

AU - Molinski, Tadeusz F.

AU - Martin, Gary E.

AU - Williamson, R. Thomas

PY - 2016/10/7

Y1 - 2016/10/7

N2 - A novel technique that allows efficient measurement of the Cl-35,Cl-37 isotope pattern for any C-13 resonance has been developed. The band-selective CLIP-HSQMBC experiment is reliable and universally applicable for the indirect measurement of the Cl-35,Cl-37 isotope shift of C-13 resonances. The experiment provides advantages over conventional 1D C-13 NMR. and the recently developed bs-HSQC experiments. The utility and performance of the bs-CLIP-HSQMBC experiment is demonstrated for polyhalogenated synthons in a synthetic route and for a polyhalogenated marine natural product.

AB - A novel technique that allows efficient measurement of the Cl-35,Cl-37 isotope pattern for any C-13 resonance has been developed. The band-selective CLIP-HSQMBC experiment is reliable and universally applicable for the indirect measurement of the Cl-35,Cl-37 isotope shift of C-13 resonances. The experiment provides advantages over conventional 1D C-13 NMR. and the recently developed bs-HSQC experiments. The utility and performance of the bs-CLIP-HSQMBC experiment is demonstrated for polyhalogenated synthons in a synthetic route and for a polyhalogenated marine natural product.

KW - Quantum coherence

KW - Natural-products

KW - Chemical-shifts

KW - Assignment

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DO - 10.1021/acs.orglett.6b02158

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SP - 4786

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JO - Organic Letters

JF - Organic Letters

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ER -

Band-Selective 2D HSQMBC: A Universal Technique for Detection and Measurement of <SUP>35,37</SUP>Cl Isotope Effects for <SUP>13</SUP>C Nuclei

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