Bacterial 1,3-1,4-β-glucanases: Structure, function and protein engineering

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1,3-1,4-β-Glucanases (or lichenases, EC hydrolyse linear β-glucans containing β-1,3 and β-1,4 linkages such as cereal β-glucans and lichenan, with a strict cleavage specificity for β-1,4 glycosidic bonds on 3-O-substituted glucosyl residues. The bacterial enzymes are retaining glycosyl hydrolases of family 16 with a jellyroll β-sandwich fold and a substrate binding cleft composed of six subsites. The present paper reviews the structure-function aspects of the enzymatic action including mechanistic enzymology, protein engineering and X-ray crystallographic studies.

Idioma originalAnglès
Pàgines (de-a)361-382
Nombre de pàgines22
RevistaBiochimica et Biophysica Acta - Protein Structure and Molecular Enzymology
Estat de la publicacióPublicada - 29 de des. 2000


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