TY - JOUR
T1 - Artemia species:An Important Tool to Screen General Toxicity Samples
T2 - An Important Tool to Screen General Toxicity Samples
AU - Ntungwe, Epolc N.
AU - Dominguez-Martin, Eva M.
AU - Roberto, Amilcar
AU - Tavares, Joana
AU - Isca, Vera M. S.
AU - Pereira, Paula
AU - Cebola, Maria-Joao
AU - Rijo, Patricia
N1 - Publisher Copyright:
© 2020 Bentham Science Publishers.
PY - 2020
Y1 - 2020
N2 - Medicinal plants are a good source of novel therapeutic drugs, due to the phytochemicals present. Anemia, commonly known as brine shrimp, is a tiny halophilic invertebrate belonging to class Crustacean, which plays an important role in saline aquatic and marine eco-systems. Besides its usage in aquaculture, it is also highly valued for its application in toxicity detection and it is used in areas such as Ecology, Physiology, Ecotoxicology, Aquaculture and Genetics. Furthermore, Artemia based lethality assay (brine shrimp lethality assay, BSLA) is rapid, convenient and low cost. Presently, brine shrimp lethality assays are enormously employed in research and applied toxicology. It has been used in the study of natural products as a preliminary toxicity assay to screen a large number of extracts and compounds for drug discovery in medicinal plants. The aim of this review paper is to collect, organize, select and discuss the existing knowledge about the different uses of Artemia salina as a bench-top bioassay for the discovery and purification of bioactive natural products.
AB - Medicinal plants are a good source of novel therapeutic drugs, due to the phytochemicals present. Anemia, commonly known as brine shrimp, is a tiny halophilic invertebrate belonging to class Crustacean, which plays an important role in saline aquatic and marine eco-systems. Besides its usage in aquaculture, it is also highly valued for its application in toxicity detection and it is used in areas such as Ecology, Physiology, Ecotoxicology, Aquaculture and Genetics. Furthermore, Artemia based lethality assay (brine shrimp lethality assay, BSLA) is rapid, convenient and low cost. Presently, brine shrimp lethality assays are enormously employed in research and applied toxicology. It has been used in the study of natural products as a preliminary toxicity assay to screen a large number of extracts and compounds for drug discovery in medicinal plants. The aim of this review paper is to collect, organize, select and discuss the existing knowledge about the different uses of Artemia salina as a bench-top bioassay for the discovery and purification of bioactive natural products.
KW - Anemia
KW - Alternative model
KW - Brine shrimp
KW - Correlation
KW - General toxicity
KW - Natural products
KW - Screening
UR - http://www.scopus.com/inward/record.url?scp=85087861281&partnerID=8YFLogxK
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=pure_univeritat_ramon_llull&SrcAuth=WosAPI&KeyUT=WOS:000552019100008&DestLinkType=FullRecord&DestApp=WOS_CPL
U2 - 10.2174/1381612826666200406083035
DO - 10.2174/1381612826666200406083035
M3 - Review
C2 - 32250221
SN - 1381-6128
VL - 26
SP - 2892
EP - 2908
JO - Current Pharmaceutical Design
JF - Current Pharmaceutical Design
IS - 24
ER -