Arousal-induced cortical activity triggers lactate release from astrocytes

Marc Zuend, Aiman S. Saab, Matthias T. Wyss, Kim David Ferrari, Ladina Hösli, Zoe J. Looser, Jillian L. Stobart, Jordi Duran, Joan J. Guinovart, L. Felipe Barros, Bruno Weber

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Resum

It has been suggested that, in states of arousal, release of noradrenaline and β-adrenergic signalling affect long-term memory formation by stimulating astrocytic lactate production from glycogen. However, the temporal relationship between cortical activity and cellular lactate fluctuations upon changes in arousal remains to be fully established. Also, the role of β-adrenergic signalling and brain glycogen metabolism on neural lactate dynamics in vivo is still unknown. Here, we show that an arousal-induced increase in cortical activity triggers lactate release into the extracellular space, and this correlates with a fast and prominent lactate dip in astrocytes. The immediate drop in astrocytic lactate concentration and the parallel increase in extracellular lactate levels underline an activity-dependent lactate release from astrocytes. Moreover, when β-adrenergic signalling is blocked or the brain is depleted of glycogen, the arousal-evoked cellular lactate surges are significantly reduced. We provide in vivo evidence that cortical activation upon arousal triggers lactate release from astrocytes, a rise in intracellular lactate levels mediated by β-adrenergic signalling and the mobilization of lactate from glycogen stores.

Idioma originalAnglès
Pàgines (de-a)179-191
Nombre de pàgines13
RevistaNature Metabolism
Volum2
Número2
DOIs
Estat de la publicacióPublicada - 1 de febr. 2020
Publicat externament

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