Applying the retro-enantio approach to obtain a peptide capable of overcoming the blood-brain barrier

Roger Prades, Benjamí Oller-Salvia, Susanne M. Schwarzmaier, Javier Selva, María Moros, Matilde Balbi, Valeria Grazú, Jesus M. De La Fuente, Gustavo Egea, Nikolaus Plesnila, Meritxell Teixidõ, Ernest Giralt

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Resum

The blood-brain barrier (BBB) is a formidable physical and enzymatic barrier that tightly controls the passage of molecules from the blood to the brain. In fact, less than 2 % of all potential neurotherapeutics are able to cross it. Here, by applying the retro-enantio approach to a peptide that targets the transferrin receptor, a full protease-resistant peptide with the capacity to act as a BBB shuttle was obtained and thus enabled the transport of a variety of cargos into the central nervous system.

Idioma originalAnglès
Pàgines (de-a)3967-3972
Nombre de pàgines6
RevistaAngewandte Chemie - International Edition
Volum54
Número13
DOIs
Estat de la publicacióPublicada - 23 de març 2015
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