Anthropometric measures and epithelial ovarian cancer risk in the European Prospective Investigation into Cancer and Nutrition

Petra H. Lahmann, Anne E. Cust, Christine M. Friedenreich, Mandy Schulz, Annekatrin Lukanova, Rudolf Kaaks, Eva Lundin, Anne Tjønneland, Jytte Halkjær, Marianne Tang Severinsen, Kim Overvad, Agnès Fournier, Nathalie Chabbert-Buffet, Françoise Clavel-Chapelon, Laure Dossus, Tobias Pischon, Heiner Boeing, Antonia Trichopoulou, Pagona Lagiou, Androniki NaskaDomenico Palli, Sara Grioni, Amalia Mattiello, Rosario Tumino, Carlotta Sacerdote, María Luisa Redondo, Paula Jakszyn, María José Sánchez, María José Tormo, Eva Ardanaz, Larraitz Arriola, Jonas Manjer, Karin Jirström, H. Bas Bueno-de-Mesquita, Anne M. May, Petra H.M. Peeters, N. Charlotte Onland-Moret, Sheila Bingham, Kay Tee Khaw, Naomi E. Allen, Elizabeth Spencer, Sabina Rinaldi, Nadia Slimani, Véronique Chajes, Dominique Michaud, Teresa Norat, Elio Riboli

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We examined the associations of measured anthropometric factors, including general and central adiposity and height, with ovarian cancer risk. We also investigated these associations by menopausal status and for specific histological subtypes. Among 226,798 women in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, there were 611 incident cases of primary, malignant, epithelial ovarian cancer diagnosed during a mean 8.9 years of follow-up. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs), adjusted for potential confounders. Compared to women with body mass index (BMI) < 25 kg/m 2, obesity (BMI ≥ 30 kg/m2) was associated with excess ovarian cancer risk for all women combined (HR = 1.33, 95% CI = 1.05-1.68; ptrend = 0.02) and postmenopausal women (HR = 1.59, 95% CI = 1.20-2.10; ptrend = 0.001), but the association was weaker for premenopausal women (HR = 1.16, 95% CI = 0.65-2.06; ptrend = 0.65). Neither height or weight gain, nor BMI-adjusted measures of fat distribution assessed by waist circumference, waist-hip ratio (WHR) or hip circumference were associated with overall risk. WHR was related to increased risk of mucinous tumors (BMIadjusted HR per 0.05 unit increment = 1.17, 95% CI = 1.00-1.38). For all women combined, no other significant associations with risk were observed for specific histological subtypes. This large, prospective study provides evidence that obesity is an important modifiable risk factor for epithelial ovarian cancer, particularly among postmenopausal women.

Idioma originalAnglès
Pàgines (de-a)2404-2415
Nombre de pàgines12
RevistaInternational Journal of Cancer
Estat de la publicacióPublicada - 15 de maig 2010
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