TY - JOUR
T1 - Anthropometric characteristics and non-Hodgkin's lymphoma and multiple myeloma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)
AU - Britton, Julie A.
AU - Khan, Aneire E.
AU - Rohrmann, Sabine
AU - Becker, Nikolaus
AU - Linseisen, Jakob
AU - Nieters, Alexandra
AU - Kaaks, Rudolf
AU - Tjønneland, Anne
AU - Halkjær, Jytte
AU - Severinsen, Marianne Tang
AU - Overvad, Kim
AU - Pischon, Tobias
AU - Boeing, Heiner
AU - Trichopoulou, Antonia
AU - Kalapothaki, Victoria
AU - Trichopoulos, Dimitrios
AU - Mattiello, Amalia
AU - Tagliabue, Giovanna
AU - Sacerdote, Carlotta
AU - Peeters, Petra H.M.
AU - Bueno-de-Mesquita, H. Bas
AU - Ardanaz, Eva
AU - Navarro, Carmen
AU - Jakszyn, Paula
AU - Altzibar, Jone M.
AU - Hallmans, Göran
AU - Malmer, Beatrice
AU - Berglund, Göran
AU - Manjer, Jonas
AU - Allen, Naomi
AU - Key, Timothy
AU - Bingham, Sheila
AU - Besson, Hervé
AU - Ferrari, Pietro
AU - Jenab, Mazda
AU - Boffetta, Paolo
AU - Vineis, Paolo
AU - Riboli, Elio
PY - 2008/11
Y1 - 2008/11
N2 - Background: The incidences of non-Hodgkin's lymphoma and multiple myeloma are increasing steadily. It has been hypothesized that this may be due, in part, to the parallel rising prevalence of obesity. It is biologically plausible that anthropometric characteristics can infuence the risk of non-Hodgkin's lymphoma and multiple myeloma. Design and Methods: In the context of the European Prospective Investigation into Cancer and Nutrition (EPIC), anthropometric characteristics were assessed in 371,983 cancer-free individuals at baseline. During the 8.5 years of follow-up, 1,219 histologically confirmed incident cases of non-Hodgkin's lymphoma and multiple myeloma occurred in 609 men and 610 women. Gender-specific proportional hazards models were used to estimate relative risks and 95% confidence intervals (95% CI) of development of non-Hodgkin's lymphoma and multiple myeloma in relation to the anthropometric characteristics. Results: Height was associated with overall non-Hodgkin's lymphoma and multiple myeloma in women (RR 1.50, 95% CI 1.14-1.98) for highest versus lowest quartile; p-trend < 0.01) but not in men. Neither obesity (weight and body mass index) nor abdominal fat (waist-to-hip ratio, waist or hip circumference) measures were positively associated with overall non-Hodgkin's lymphoma and multiple myeloma. Relative risks for highest versus lowest body mass index quartile were 1.09 (95% CI 0.85-1.38) and 0.92 (95% CI 0.71-1.19) for men and women, respectively. Women in the upper body mass index quartile were at greater risk of diffuse large B-cell lymphoma (RR 2.18, 95% CI 1.05-4.53) and taller women had an elevated risk of follicular lymphoma (RR 1.25, 95% CI 0.59-2.62). Among men, height and body mass index were non-significantly, positively related to follicular lymphoma. Multiple myeloma risk alone was elevated for taller women (RR 2.34, 95% CI 1.29-4.21) and heavier men (RR 1.77, 95% CI 1.02-3.05). Conclusions: The EPIC analyses support an association between height and overall non-Hodgkin's lymphoma and multiple myeloma among women and suggest heterogeneous subtype associations. This is one of the first prospective studies focusing on central adiposity and non-Hodgkin's lymphoma subtypes.
AB - Background: The incidences of non-Hodgkin's lymphoma and multiple myeloma are increasing steadily. It has been hypothesized that this may be due, in part, to the parallel rising prevalence of obesity. It is biologically plausible that anthropometric characteristics can infuence the risk of non-Hodgkin's lymphoma and multiple myeloma. Design and Methods: In the context of the European Prospective Investigation into Cancer and Nutrition (EPIC), anthropometric characteristics were assessed in 371,983 cancer-free individuals at baseline. During the 8.5 years of follow-up, 1,219 histologically confirmed incident cases of non-Hodgkin's lymphoma and multiple myeloma occurred in 609 men and 610 women. Gender-specific proportional hazards models were used to estimate relative risks and 95% confidence intervals (95% CI) of development of non-Hodgkin's lymphoma and multiple myeloma in relation to the anthropometric characteristics. Results: Height was associated with overall non-Hodgkin's lymphoma and multiple myeloma in women (RR 1.50, 95% CI 1.14-1.98) for highest versus lowest quartile; p-trend < 0.01) but not in men. Neither obesity (weight and body mass index) nor abdominal fat (waist-to-hip ratio, waist or hip circumference) measures were positively associated with overall non-Hodgkin's lymphoma and multiple myeloma. Relative risks for highest versus lowest body mass index quartile were 1.09 (95% CI 0.85-1.38) and 0.92 (95% CI 0.71-1.19) for men and women, respectively. Women in the upper body mass index quartile were at greater risk of diffuse large B-cell lymphoma (RR 2.18, 95% CI 1.05-4.53) and taller women had an elevated risk of follicular lymphoma (RR 1.25, 95% CI 0.59-2.62). Among men, height and body mass index were non-significantly, positively related to follicular lymphoma. Multiple myeloma risk alone was elevated for taller women (RR 2.34, 95% CI 1.29-4.21) and heavier men (RR 1.77, 95% CI 1.02-3.05). Conclusions: The EPIC analyses support an association between height and overall non-Hodgkin's lymphoma and multiple myeloma among women and suggest heterogeneous subtype associations. This is one of the first prospective studies focusing on central adiposity and non-Hodgkin's lymphoma subtypes.
KW - Anthropometry
KW - Cohort study
KW - Non-Hodgkin's lymphoma
UR - http://www.scopus.com/inward/record.url?scp=55549091706&partnerID=8YFLogxK
U2 - 10.3324/haematol.13078
DO - 10.3324/haematol.13078
M3 - Article
C2 - 18835833
AN - SCOPUS:55549091706
SN - 0390-6078
VL - 93
SP - 1666
EP - 1677
JO - Haematologica
JF - Haematologica
IS - 11
ER -
