TY - JOUR
T1 - Analysis of 44 pharmaceuticals consumed by elderly using liquid chromatography coupled to tandem mass spectrometry
AU - Gómez-Canela, Cristian
AU - Sala-Comorera, Teresa
AU - Pueyo, Víctor
AU - Barata, Carlos
AU - Lacorte, Silvia
N1 - Funding Information:
This study has been financed by the SUDOE program with the project Innovec’EAU (2016-2019)/Project SOE1/P1/F0173 Interreg Sudoe funded by FEDER ( http://innovec-eau.univ-perp.fr ). We would like to acknowledge the associated partners of the project: Jordi Cayetano and Marc Antoni Rovira from Sant Joan de Deu (SJD) and Cinta Pascual, Arnald Pannocchia and Nuria Urquiz from Llars d’Avis de Catalunya (L’Onada). We would also like to thank the personnel from the elderly establishments for their assistance and guidance and for providing consumption data of pharmaceuticals.
Funding Information:
This study has been financed by the SUDOE program with the project Innovec'EAU (2016-2019)/Project SOE1/P1/F0173 Interreg Sudoe funded by FEDER (http://innovec-eau.univ-perp.fr). We would like to acknowledge the associated partners of the project: Jordi Cayetano and Marc Antoni Rovira from Sant Joan de Deu (SJD) and Cinta Pascual, Arnald Pannocchia and Nuria Urquiz from Llars d'Avis de Catalunya (L'Onada). We would also like to thank the personnel from the elderly establishments for their assistance and guidance and for providing consumption data of pharmaceuticals.
Publisher Copyright:
© 2019
PY - 2019/5/10
Y1 - 2019/5/10
N2 - Elderly people represent about the 15% of the total world population and often include a polymedicated age group with an average consumption of 5–10 pills per day. The main pharmaceuticals consumed are antianalgesics, antidiabetics, anti-parkinson compounds, anti-convulsants, drugs to treat constipation and drugs to treat cancer. In this study, we have developed a multiresidue method for the analysis of 44 selected pharmaceuticals prioritized according to the foremost consumption by the elderly in effluents from senior residences. Given the complexity of these waters, method optimization included the selection of the extraction cartridge, pH and volume, and the optimization of the liquid chromatography-tandem mass spectrometry conditions to minimize matrix effects and obtain high yields. Good method performance was obtained, with recoveries between 27 and 116% and high sensitivity. The method was tested in a preliminar study to determine pharmaceuticals released in situ from the untreated effluents of the senior residences. High concentrations were detected, with levels between 0.20 and 2891 μg L −1 attributed to the high consumption of drugs in the studied residences, which gather around 100 residents. The most detected pharmaceuticals were aspirin, macrogol, levofloxacin, cyclophosphamide, diclofenac, ibuprofen, paracetamol, carbamazepine, levetiracetam, pregabalin, quetiapine, chlormetiazole, trazodone, caffeine, 2,4-dichlorobenzyl alcohol and amylmetacresol. This study describes the analytical conditions to determine the outmost consumed pharmaceuticals in wastewaters released from senior residences.
AB - Elderly people represent about the 15% of the total world population and often include a polymedicated age group with an average consumption of 5–10 pills per day. The main pharmaceuticals consumed are antianalgesics, antidiabetics, anti-parkinson compounds, anti-convulsants, drugs to treat constipation and drugs to treat cancer. In this study, we have developed a multiresidue method for the analysis of 44 selected pharmaceuticals prioritized according to the foremost consumption by the elderly in effluents from senior residences. Given the complexity of these waters, method optimization included the selection of the extraction cartridge, pH and volume, and the optimization of the liquid chromatography-tandem mass spectrometry conditions to minimize matrix effects and obtain high yields. Good method performance was obtained, with recoveries between 27 and 116% and high sensitivity. The method was tested in a preliminar study to determine pharmaceuticals released in situ from the untreated effluents of the senior residences. High concentrations were detected, with levels between 0.20 and 2891 μg L −1 attributed to the high consumption of drugs in the studied residences, which gather around 100 residents. The most detected pharmaceuticals were aspirin, macrogol, levofloxacin, cyclophosphamide, diclofenac, ibuprofen, paracetamol, carbamazepine, levetiracetam, pregabalin, quetiapine, chlormetiazole, trazodone, caffeine, 2,4-dichlorobenzyl alcohol and amylmetacresol. This study describes the analytical conditions to determine the outmost consumed pharmaceuticals in wastewaters released from senior residences.
KW - LC–MS/MS
KW - Pharmaceuticals
KW - Senior residences
KW - Wastewater
UR - http://www.scopus.com/inward/record.url?scp=85061827079&partnerID=8YFLogxK
U2 - 10.1016/j.jpba.2019.02.016
DO - 10.1016/j.jpba.2019.02.016
M3 - Article
C2 - 30784890
AN - SCOPUS:85061827079
SN - 0731-7085
VL - 168
SP - 55
EP - 63
JO - Journal of Pharmaceutical and Biomedical Analysis
JF - Journal of Pharmaceutical and Biomedical Analysis
ER -
