TY - JOUR
T1 - Advanced oxidation of the antibiotic sulfapyridine by UV/H2O2
T2 - Characterization of its transformation products and ecotoxicological implications
AU - García-Galán, Ma Jesús
AU - Anfruns, Alba
AU - Gonzalez-Olmos, Rafael
AU - Rodriguez-Mozaz, Sara
AU - Comas, Joaquim
N1 - Funding Information:
The research leading to these results has received funding from by the European projects Atwat ( PCIN-2013-074 ) and Marie Curie SANITAS ITN ( 289193 ) and the Spanish Ministry of Economy and Competitiveness (projects CTM2012-38314-C02-01 and CTM2013-48545-C2 ). R. Gonzalez-Olmos thanks to “Obra Social La Caixa” for funding through the University Ramon Llull Tractor project “Electromembrane” ( 2014-URL-Trac-002 ). ICRA research activity has been cofinanced by the Spanish Ministry of Economy and Competitiveness (MINECO) and by the European Regional Development Fund (ERDF) in the frame of the Catalonia ERDF Operative programm 2007–2013. Dr. M.J.García would like to thank to M. Villagrasa, S. Insa and M. Llorca for their assistance and help with all the analytical equipment.
Publisher Copyright:
© 2015 Elsevier Ltd.
PY - 2016/3/1
Y1 - 2016/3/1
N2 - The aim of the present work is to investigate, under lab-scale conditions, the removal and transformation of the antibiotic sulfapyridine (SPY) upon advanced oxidation with UV/H2O2. High resolution mass spectrometry (HRMS) analyses by means of an ultra-high pressure liquid chromatography (UHPLC)-linear ion trap high resolution Orbitrap instrument (LTQ-Orbitrap-MS) were carried out in order to elucidate the different transformation products (TPs) generated. The abatement (>99%) of the antibiotic was only achieved after 180 min, highlighting its resilience to elimination and its potential persistence in the environment A total of 10 TPs for SPY were detected and their molecular structures elucidated by means of MS2 and MS3 scans. Finally, the combined ecotoxicity at different treatment times was evaluated by means of bioluminescence inhibition assays with the marine bacteria Vibrio fischeri.
AB - The aim of the present work is to investigate, under lab-scale conditions, the removal and transformation of the antibiotic sulfapyridine (SPY) upon advanced oxidation with UV/H2O2. High resolution mass spectrometry (HRMS) analyses by means of an ultra-high pressure liquid chromatography (UHPLC)-linear ion trap high resolution Orbitrap instrument (LTQ-Orbitrap-MS) were carried out in order to elucidate the different transformation products (TPs) generated. The abatement (>99%) of the antibiotic was only achieved after 180 min, highlighting its resilience to elimination and its potential persistence in the environment A total of 10 TPs for SPY were detected and their molecular structures elucidated by means of MS2 and MS3 scans. Finally, the combined ecotoxicity at different treatment times was evaluated by means of bioluminescence inhibition assays with the marine bacteria Vibrio fischeri.
KW - Ecotoxicity
KW - Metabolite
KW - Sulfapyridine
KW - Transformation products
KW - UV/HO oxidation
UR - http://www.scopus.com/inward/record.url?scp=84957809775&partnerID=8YFLogxK
U2 - 10.1016/j.chemosphere.2015.12.108
DO - 10.1016/j.chemosphere.2015.12.108
M3 - Article
C2 - 26789837
AN - SCOPUS:84957809775
SN - 0045-6535
VL - 147
SP - 451
EP - 459
JO - Chemosphere
JF - Chemosphere
ER -
