Adrenomedullin is a useful biomarker for the prognosis of critically ill septic children

Iolanda Jordan; Patricia Corniero; Mònica Balaguer; Jessica Ortiz; David Vila; Jesús Velasco; Francisco J. Cambra; Elisabeth Esteban

doi:10.2217/BMM.14.77

Adrenomedullin is a useful biomarker for the prognosis of critically ill septic children

Iolanda Jordan, Patricia Corniero, Mònica Balaguer, Jessica Ortiz, David Vila, Jesús Velasco, Francisco J. Cambra, Elisabeth Esteban

Producció científica: Article en revista indexada › Article › Avaluat per experts

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Aim: To measure midregional pro-adrenomedullin (MR-pro-ADM) in critically ill septic patients to determine its prognostic usefulness as compared with other used biomarkers in pediatric intensive care units, C-reactive protein (CRP) and procalcitonin (PCT). Materials & methods: Prospective observational study conducted on 95 patients. Results: Mean levels of MR-pro-ADM were significantly higher when patients needed mechanical ventilation (3.2 ± 4.3 vs 1.6 ± 2.4) and inotropes (4.4 ± 5.2 vs 1.3 ± 1.2). Receiver operating characteristic curves of mortality were higher for MR-pro-ADM (cut-off value of 2.2). This marker showed higher positive predictive prognostic value than PCT and CRP (31 vs 21.6% and 15.8%, respectively). Conclusion: MR-pro-ADM levels are good indicators of disease severity and show better reliability than PCT and CRP for predicting in-hospital mortality.

Idioma original	Anglès
Pàgines (de-a)	1065-1072
Nombre de pàgines	8
Revista	Biomarkers in Medicine
Volum	8
Número	9
DOIs	https://doi.org/10.2217/BMM.14.77
Estat de la publicació	Publicada - 1 d’oct. 2014
Publicat externament	Sí

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@article{2953a3e8822246c4bcbe9e5312b52bce,

title = "Adrenomedullin is a useful biomarker for the prognosis of critically ill septic children",

abstract = "Aim: To measure midregional pro-adrenomedullin (MR-pro-ADM) in critically ill septic patients to determine its prognostic usefulness as compared with other used biomarkers in pediatric intensive care units, C-reactive protein (CRP) and procalcitonin (PCT). Materials & methods: Prospective observational study conducted on 95 patients. Results: Mean levels of MR-pro-ADM were significantly higher when patients needed mechanical ventilation (3.2 ± 4.3 vs 1.6 ± 2.4) and inotropes (4.4 ± 5.2 vs 1.3 ± 1.2). Receiver operating characteristic curves of mortality were higher for MR-pro-ADM (cut-off value of 2.2). This marker showed higher positive predictive prognostic value than PCT and CRP (31 vs 21.6% and 15.8%, respectively). Conclusion: MR-pro-ADM levels are good indicators of disease severity and show better reliability than PCT and CRP for predicting in-hospital mortality.",

keywords = "Adrenomedullin, C-reactive protein, Diagnostic, Procalcitonin, Sepsis",

author = "Iolanda Jordan and Patricia Corniero and M{\`o}nica Balaguer and Jessica Ortiz and David Vila and Jes{\'u}s Velasco and Cambra, {Francisco J.} and Elisabeth Esteban",

note = "Publisher Copyright: {\textcopyright} 2014 Future Medicine Ltd.",

year = "2014",

month = oct,

day = "1",

doi = "10.2217/BMM.14.77",

language = "English",

volume = "8",

pages = "1065--1072",

journal = "Biomarkers in Medicine",

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TY - JOUR

T1 - Adrenomedullin is a useful biomarker for the prognosis of critically ill septic children

AU - Jordan, Iolanda

AU - Corniero, Patricia

AU - Balaguer, Mònica

AU - Ortiz, Jessica

AU - Vila, David

AU - Velasco, Jesús

AU - Cambra, Francisco J.

AU - Esteban, Elisabeth

PY - 2014/10/1

Y1 - 2014/10/1

N2 - Aim: To measure midregional pro-adrenomedullin (MR-pro-ADM) in critically ill septic patients to determine its prognostic usefulness as compared with other used biomarkers in pediatric intensive care units, C-reactive protein (CRP) and procalcitonin (PCT). Materials & methods: Prospective observational study conducted on 95 patients. Results: Mean levels of MR-pro-ADM were significantly higher when patients needed mechanical ventilation (3.2 ± 4.3 vs 1.6 ± 2.4) and inotropes (4.4 ± 5.2 vs 1.3 ± 1.2). Receiver operating characteristic curves of mortality were higher for MR-pro-ADM (cut-off value of 2.2). This marker showed higher positive predictive prognostic value than PCT and CRP (31 vs 21.6% and 15.8%, respectively). Conclusion: MR-pro-ADM levels are good indicators of disease severity and show better reliability than PCT and CRP for predicting in-hospital mortality.

AB - Aim: To measure midregional pro-adrenomedullin (MR-pro-ADM) in critically ill septic patients to determine its prognostic usefulness as compared with other used biomarkers in pediatric intensive care units, C-reactive protein (CRP) and procalcitonin (PCT). Materials & methods: Prospective observational study conducted on 95 patients. Results: Mean levels of MR-pro-ADM were significantly higher when patients needed mechanical ventilation (3.2 ± 4.3 vs 1.6 ± 2.4) and inotropes (4.4 ± 5.2 vs 1.3 ± 1.2). Receiver operating characteristic curves of mortality were higher for MR-pro-ADM (cut-off value of 2.2). This marker showed higher positive predictive prognostic value than PCT and CRP (31 vs 21.6% and 15.8%, respectively). Conclusion: MR-pro-ADM levels are good indicators of disease severity and show better reliability than PCT and CRP for predicting in-hospital mortality.

KW - Adrenomedullin

KW - C-reactive protein

KW - Diagnostic

KW - Procalcitonin

KW - Sepsis

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U2 - 10.2217/BMM.14.77

DO - 10.2217/BMM.14.77

M3 - Article

C2 - 25402577

AN - SCOPUS:84911481192

SN - 1752-0363

VL - 8

SP - 1065

EP - 1072

JO - Biomarkers in Medicine

JF - Biomarkers in Medicine

IS - 9

ER -

Adrenomedullin is a useful biomarker for the prognosis of critically ill septic children

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