TY - JOUR
T1 - Absorbing knowledge from an emerging field
T2 - The role of interfacing by proponents in big pharma
AU - Romasanta, A. K.
AU - van der Sijde, Peter
AU - de Esch, Iwan J.P.
N1 - Publisher Copyright:
© 2021 The Authors
PY - 2022/2
Y1 - 2022/2
N2 - Engaging with knowledge from an emerging field, with its promises and limitations still uncertain, can be challenging for incumbent firms. Proponents of novel technologies within these firms then play an important role in bridging the developments in the field with the rest of the firm. In this study, we explore how researchers in big pharma firms engaged with knowledge from a promising, yet once-speculative approach called fragment-based drug discovery (FBDD). To set the context, we mapped the publications and drugs in clinical trials coming from this approach across big pharma firms. Through our unique access to researchers in two big pharma firms (an early and a late adopter), we conducted a case study to explore how researchers built the capability within their firms. We find that at each stage of knowledge absorption (search and recognize value, assimilate, acquire, transform and exploit), proponents perform both internal- and external-facing activities to overcome uncertainties with regards to the field. We find that the emphasis of these activities evolves over time as the field evolves. In the early days of the field, proponents of the approach motivated knowledge absorption by emphasizing the internal needs of the firm. As the field matured, with its value becoming increasingly known, proponents lean on the exciting developments in the field to motivate further the adoption of the technology. In general, we find that proponents strategically tuned their external activities to cater to their internal context and similarly, adapted their internal activities to reflect external developments. By exploring interfacing in an emerging field, this study provides insights into how practitioners in large incumbent firms can adapt to the emergence of novel technologies.
AB - Engaging with knowledge from an emerging field, with its promises and limitations still uncertain, can be challenging for incumbent firms. Proponents of novel technologies within these firms then play an important role in bridging the developments in the field with the rest of the firm. In this study, we explore how researchers in big pharma firms engaged with knowledge from a promising, yet once-speculative approach called fragment-based drug discovery (FBDD). To set the context, we mapped the publications and drugs in clinical trials coming from this approach across big pharma firms. Through our unique access to researchers in two big pharma firms (an early and a late adopter), we conducted a case study to explore how researchers built the capability within their firms. We find that at each stage of knowledge absorption (search and recognize value, assimilate, acquire, transform and exploit), proponents perform both internal- and external-facing activities to overcome uncertainties with regards to the field. We find that the emphasis of these activities evolves over time as the field evolves. In the early days of the field, proponents of the approach motivated knowledge absorption by emphasizing the internal needs of the firm. As the field matured, with its value becoming increasingly known, proponents lean on the exciting developments in the field to motivate further the adoption of the technology. In general, we find that proponents strategically tuned their external activities to cater to their internal context and similarly, adapted their internal activities to reflect external developments. By exploring interfacing in an emerging field, this study provides insights into how practitioners in large incumbent firms can adapt to the emergence of novel technologies.
KW - Absorptive capacity
KW - Drug discovery
KW - Innovation adoption
KW - Pharmaceutical industry
KW - Research and development
UR - http://www.scopus.com/inward/record.url?scp=85113655022&partnerID=8YFLogxK
U2 - 10.1016/j.technovation.2021.102363
DO - 10.1016/j.technovation.2021.102363
M3 - Article
AN - SCOPUS:85113655022
SN - 0166-4972
VL - 110
JO - Technovation
JF - Technovation
M1 - 102363
ER -