A novel fluoro-chromogenic click reaction for the labelling of proteins and nanoparticles with near-IR theranostic agents

Oriol Planas; Thibault Gallavardin; Santi Nonell

doi:10.1039/c4cc09070e

A novel fluoro-chromogenic click reaction for the labelling of proteins and nanoparticles with near-IR theranostic agents

Oriol Planas, Thibault Gallavardin, Santi Nonell

Producció científica: Article en revista indexada › Article › Avaluat per experts

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Resum

Reaction of porphycene isothiocyanates with primary and secondary amines leads to the formation of thiazolo[4,5-c]porphycenes, with a substantial shift in the absorption and fluorescence spectra. The conjugates show fluorescence in the near-infrared and are capable of photosensitizing the production of the cytotoxic species singlet oxygen.

Idioma original	Anglès
Pàgines (de-a)	5586-5589
Nombre de pàgines	4
Revista	Chemical Communications
Volum	51
Número	26
DOIs	https://doi.org/10.1039/c4cc09070e
Estat de la publicació	Publicada - 4 d’abr. 2015

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title = "A novel fluoro-chromogenic click reaction for the labelling of proteins and nanoparticles with near-IR theranostic agents",

abstract = "Reaction of porphycene isothiocyanates with primary and secondary amines leads to the formation of thiazolo[4,5-c]porphycenes, with a substantial shift in the absorption and fluorescence spectra. The conjugates show fluorescence in the near-infrared and are capable of photosensitizing the production of the cytotoxic species singlet oxygen.",

keywords = "Photodynamic therapy, Photophysical properties, Probe-design, Live-cell, Porphycene, Fluorescence, 2-aminobenzothiazoles, Photosensitizer, Derivatives, Cancer",

author = "Oriol Planas and Thibault Gallavardin and Santi Nonell",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2015.",

year = "2015",

month = apr,

day = "4",

doi = "10.1039/c4cc09070e",

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T1 - A novel fluoro-chromogenic click reaction for the labelling of proteins and nanoparticles with near-IR theranostic agents

AU - Planas, Oriol

AU - Gallavardin, Thibault

AU - Nonell, Santi

N1 - Publisher Copyright: © The Royal Society of Chemistry 2015.

PY - 2015/4/4

Y1 - 2015/4/4

N2 - Reaction of porphycene isothiocyanates with primary and secondary amines leads to the formation of thiazolo[4,5-c]porphycenes, with a substantial shift in the absorption and fluorescence spectra. The conjugates show fluorescence in the near-infrared and are capable of photosensitizing the production of the cytotoxic species singlet oxygen.

AB - Reaction of porphycene isothiocyanates with primary and secondary amines leads to the formation of thiazolo[4,5-c]porphycenes, with a substantial shift in the absorption and fluorescence spectra. The conjugates show fluorescence in the near-infrared and are capable of photosensitizing the production of the cytotoxic species singlet oxygen.

KW - Photodynamic therapy

KW - Photophysical properties

KW - Probe-design

KW - Live-cell

KW - Porphycene

KW - Fluorescence

KW - 2-aminobenzothiazoles

KW - Photosensitizer

KW - Derivatives

KW - Cancer

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DO - 10.1039/c4cc09070e

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SN - 1359-7345

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JO - Chemical Communications

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ER -

A novel fluoro-chromogenic click reaction for the labelling of proteins and nanoparticles with near-IR theranostic agents

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