A genetically-encoded photosensitiser demonstrates killing of bacteria by purely endogenous singlet oxygen

Rubén Ruiz-González; John H. White; Montserrat Agut; Santi Nonell; Cristina Flors

doi:10.1039/c2pp25126d

A genetically-encoded photosensitiser demonstrates killing of bacteria by purely endogenous singlet oxygen

Rubén Ruiz-González, John H. White, Montserrat Agut, Santi Nonell, Cristina Flors

Producció científica: Article en revista indexada › Article › Avaluat per experts

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TagRFP, a fluorescent protein capable of photosensitizing the production of singlet oxygen, was expressed in E. coli. Subsequent exposure to green light induced bacterial cell death in a light-dose dependent manner. It is demonstrated for the first time that intracellular singlet oxygen is sufficient to kill bacteria.

Idioma original	Anglès
Pàgines (de-a)	1411-1413
Nombre de pàgines	3
Revista	Photochemical and Photobiological Sciences
Volum	11
Número	9
DOIs	https://doi.org/10.1039/c2pp25126d
Estat de la publicació	Publicada - de set. 2012

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title = "A genetically-encoded photosensitiser demonstrates killing of bacteria by purely endogenous singlet oxygen",

abstract = "TagRFP, a fluorescent protein capable of photosensitizing the production of singlet oxygen, was expressed in E. coli. Subsequent exposure to green light induced bacterial cell death in a light-dose dependent manner. It is demonstrated for the first time that intracellular singlet oxygen is sufficient to kill bacteria.",

keywords = "Photodynamic therapy, Escherichia-coli, Inactivation, Light",

author = "Rub{\'e}n Ruiz-Gonz{\'a}lez and White, {John H.} and Montserrat Agut and Santi Nonell and Cristina Flors",

year = "2012",

month = sep,

doi = "10.1039/c2pp25126d",

language = "English",

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T1 - A genetically-encoded photosensitiser demonstrates killing of bacteria by purely endogenous singlet oxygen

AU - Ruiz-González, Rubén

AU - White, John H.

AU - Agut, Montserrat

AU - Nonell, Santi

AU - Flors, Cristina

PY - 2012/9

Y1 - 2012/9

N2 - TagRFP, a fluorescent protein capable of photosensitizing the production of singlet oxygen, was expressed in E. coli. Subsequent exposure to green light induced bacterial cell death in a light-dose dependent manner. It is demonstrated for the first time that intracellular singlet oxygen is sufficient to kill bacteria.

AB - TagRFP, a fluorescent protein capable of photosensitizing the production of singlet oxygen, was expressed in E. coli. Subsequent exposure to green light induced bacterial cell death in a light-dose dependent manner. It is demonstrated for the first time that intracellular singlet oxygen is sufficient to kill bacteria.

KW - Photodynamic therapy

KW - Escherichia-coli

KW - Inactivation

KW - Light

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DO - 10.1039/c2pp25126d

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JF - Photochemical and Photobiological Sciences

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ER -

A genetically-encoded photosensitiser demonstrates killing of bacteria by purely endogenous singlet oxygen

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