@inbook{15689bb7f7eb46e2ac90d259e28dd356,
title = "A Dynamic, In Vitro BBB Model to Study the Effects of Varying Levels of Shear Stress",
abstract = "The blood–brain barrier (BBB) consists of a tight network of blood capillaries in the brain that separate the circulatory system from the central nervous system. Its particular properties are based on the dynamic interaction between cerebral endothelial cells and other surrounding cells, especially astrocytes. We have designed and synthesized a three-dimensional scaffold that recapitulates the main hallmarks of the BBB extracellular matrix and serves as a platform to co-culture human brain microvascular endothelial cells and human cortical astrocytes. The scaffold can be exposed to flow, thereby allowing the study of flow-mediated pathways at the BBB.",
keywords = "Blood–brain barrier, Cerebrovascular disease, Flow loops, Fluid device, Shear stress, Vascular biology",
author = "{Molins Guti{\'e}rrez}, Gemma and Jordi Martorell and Salazar-Martin, {Antonio G.} and Mercedes Balcells",
note = "Funding Information: This work was supported in part by a grant from Spain Ministerio de Econom{\'i}a y Competitividad (SAF-2017-84773-C2, MB) and by the Global CoCreation Lab (GM, MB). Publisher Copyright: {\textcopyright} 2022, The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.",
year = "2022",
doi = "10.1007/978-1-0716-2289-6_10",
language = "English",
series = "Methods in Molecular Biology",
publisher = "Humana Press Inc.",
pages = "175--190",
booktitle = "Methods in Molecular Biology",
}