A diversity oriented, microwave assisted synthesis of N-substituted 2-hydro-4-amino-pyrido[2,3-d]pyrimidin-7(8H)-ones

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A protocol for the synthesis of N-substituted 2-hydro-4-amino-pyrido[2,3-d] pyrimidin-7(8H)-ones (11) is described. Thus, the formylation of a 2-aminopyridone 12 in 85% formic acid/Ac2O, proceeding via in situ cyclization to the intermediate formamide 13, affords the corresponding 2-hydro-4-oxo-pyridopyrimidine 14, which is converted to a 4-chloro- pyridopyrimidine 15 upon treatment with POCl3. The subsequent transformation to the title compounds is carried by treatment with the corresponding amine in MeOH under microwave irradiation conditions.

Idioma originalAnglès
Pàgines (de-a)39-45
Nombre de pàgines7
RevistaMolecular Diversity
Estat de la publicacióPublicada - de febr. 2009


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