TY - JOUR
T1 - A diversity-oriented, microwave-assisted synthesis of 4-oxo and 4-chloropyrido[2,3-d]pyrimidin-7(8H)-ones
AU - Mont, N.
AU - Fernández-Megido, L.
AU - Teixidó, J.
AU - Kappe, C. O.
AU - Borrell, J. I.
PY - 2004/12
Y1 - 2004/12
N2 - A microwave-assisted protocol for the synthesis of 4-oxo and 4-chloropyrido[2,3-d]pyrimidin-7(8H)-ones, 13 and 9 respectively, bearing a carbon substituent at C2 and a chlorine atom at C4 is reported. The introduction of a wide range of substituents at C2 renders this methodology easily amenable to combinatorial chemistry applications. Two examples of further derivatization of compounds 9, substitution by amine and Suzuki coupling, under microwave irradiation are also described.
AB - A microwave-assisted protocol for the synthesis of 4-oxo and 4-chloropyrido[2,3-d]pyrimidin-7(8H)-ones, 13 and 9 respectively, bearing a carbon substituent at C2 and a chlorine atom at C4 is reported. The introduction of a wide range of substituents at C2 renders this methodology easily amenable to combinatorial chemistry applications. Two examples of further derivatization of compounds 9, substitution by amine and Suzuki coupling, under microwave irradiation are also described.
KW - Combinatorial Chemistry
KW - Microwave assisted synthesis
KW - Pyrido[2,3-d]pyrimidines
KW - Suzuki coupling
UR - http://www.scopus.com/inward/record.url?scp=12344250609&partnerID=8YFLogxK
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=pure_univeritat_ramon_llull&SrcAuth=WosAPI&KeyUT=WOS:000226191600003&DestLinkType=FullRecord&DestApp=WOS
U2 - 10.1002/qsar.200420033
DO - 10.1002/qsar.200420033
M3 - Article
AN - SCOPUS:12344250609
SN - 1611-020X
VL - 23
SP - 836
EP - 849
JO - QSAR and Combinatorial Science
JF - QSAR and Combinatorial Science
IS - 10
ER -