4-Amino-2-arylamino-6-(2,6-dichlorophenyl)-pyrido[2,3- d ]pyrimidin-7-(8 H)-ones as BCR kinase inhibitors for B lymphoid malignancies

Raimon Puig De La Bellacasa, Gaël Roué, Patricia Balsas, Patricia Pérez-Galán, Jordi Teixidó, Dolors Colomer, José I. Borrell

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Resum

A new family of 4-aminopyrido[2,3-d]pyrimidines active against non-Hodgkin's lymphomas (NHLs) is described. Among these compounds, 19 inhibits the most upstream tyrosine kinases in the B cell receptor (BCR) signaling pathway which are involved in the mature B cell neoplasms. Thus, 19 showed antiproliferative activity at 24 h and 48 h against a panel of 20 NHLs cell lines with GI50 ranging from 1.3 to 6.9 Î.

Idioma originalAnglès
Pàgines (de-a)664-675
Nombre de pàgines12
RevistaEuropean Journal of Medicinal Chemistry
Volum86
DOIs
Estat de la publicacióPublicada - 30 d’oct. 2014

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