TY - JOUR
T1 - 2-Methoxy-6-oxo-1,4,5,6-tetrahydropyridine-3-carbonitriles
T2 - Versatile starting materials for the synthesis of libraries with diverse heterocyclic scaffolds
AU - Martínez-Teipel, Blanca
AU - Teixidó, Jordi
AU - Pascual, Rosalia
AU - Mora, Marta
AU - Pujolà, Josep
AU - Fujimoto, Ted
AU - Borrell, José I.
AU - Michelotti, Enrique L.
PY - 2005/5
Y1 - 2005/5
N2 - Heterocyclic demonstration libraries for agrochemical screening were prepared from the common intermediates 2-methoxy-6-oxo-1,4,5,6- tetrahydropyridine-3-carbonitriles (1), using standard solution-phase techniques. A total of 18 screening libraries were prepared in good to excellent yields. Several members of these libraries were active in the first level of agrochemical screening, especially in the fungicide screen.
AB - Heterocyclic demonstration libraries for agrochemical screening were prepared from the common intermediates 2-methoxy-6-oxo-1,4,5,6- tetrahydropyridine-3-carbonitriles (1), using standard solution-phase techniques. A total of 18 screening libraries were prepared in good to excellent yields. Several members of these libraries were active in the first level of agrochemical screening, especially in the fungicide screen.
KW - Tyrosine kinase inhibitors
KW - Hydrogen halides
KW - Irreversible inhibitors
KW - 1,5-dinitrile systems
KW - Antitumor agents
KW - Cyclization
KW - 4-(phenylamino)quinazoline
KW - Discovery
UR - http://www.scopus.com/inward/record.url?scp=20044391821&partnerID=8YFLogxK
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=pure_univeritat_ramon_llull&SrcAuth=WosAPI&KeyUT=WOS:000229055500011&DestLinkType=FullRecord&DestApp=WOS_CPL
U2 - 10.1021/cc049828y
DO - 10.1021/cc049828y
M3 - Article
C2 - 15877472
AN - SCOPUS:20044391821
SN - 1520-4766
VL - 7
SP - 436
EP - 448
JO - Journal of Combinatorial Chemistry
JF - Journal of Combinatorial Chemistry
IS - 3
ER -