Detalls del projecte
Description
The main aim of the whole project is the comparison of the immunogenic and therapeutic potential between a local vs a systemic mRNA vaccine for the treatment of metastatic melanoma. Specifically, in this call, we aim to design two different devices for the local delivery, a hollow microneedle and a polysaccharide hydrogel. Thus, the specific aims of the project are:
1) Design a polysaccharide hydrogel, embedded with antigenic mRNA-loaded pBAE nanoparticles.
2) Design of a PLGA hollow microneedle, loaded with antigenic mRNA-loaded pBAE nanoparticles.
3) In vitro confirmation of the safety and immunogenicity of both delivery systems.
1) Design a polysaccharide hydrogel, embedded with antigenic mRNA-loaded pBAE nanoparticles.
2) Design of a PLGA hollow microneedle, loaded with antigenic mRNA-loaded pBAE nanoparticles.
3) In vitro confirmation of the safety and immunogenicity of both delivery systems.
| Estatus | Acabat |
|---|---|
| Data efectiva d'inici i finalització | 6/03/24 → 31/12/24 |
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